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Evaluation of the CIB1R peptide derived from the cytoplasmic domain of neprilysin on cell migration in an in vitro model of lung cancer

Abstract: Lung cancer is characterized by high metastatic potential and poor clinical outcomes, underscoring the need for novel approaches to investigate mechanisms regulating…

Date: 2026-06-23

Early divergence of treatment response trajectories to adalimumab or its biosimilar in active ankylosing spondylitis: consensus clustering analysis of a randomized controlled trial

Abstract: Patients with active ankylosing spondylitis (AS) exhibit substantial heterogeneity in their clinical responses to tumor necrosis factor alpha inhibitors (TNFi).…

Date: 2026-06-23

Comparison of four culture protocols for differentiating bovine peripheral blood mononuclear cells into macrophages

Abstract: Macrophages are essential innate immune cells involved in host defense, tissue homeostasis, and inflammation regulation. In vitro differentiation protocols for…

Date: 2026-06-23

Data-driven trial design: use of target trial emulation to evaluate eligibility criteria in asthma and COPD

Abstract: Clinical trial eligibility criteria are crucial to ensuring valid estimation of therapeutic treatment effects and robust measurement of safety. However, highly…

Date: 2026-06-23

Post-treatment renal function deterioration following radiation therapy: implications for SABR in primary renal cell cancer

Abstract: Definitive renal stereotactic ablative radiotherapy (SABR) is gaining momentum, with promising data showing excellent local control and short-term renal function…

Date: 2026-06-23

Distribution analysis of gynecological carcinomas with concurrent second primary carcinomas

Abstract: This study investigates the distribution characteristics, occurrence time and clinicopathological correlations of second primary carcinoma (SPC) in patients with…

Date: 2026-06-23

Mortality trends and disparities in older U.S. adults with atrial fibrillation and COPD: a 1999–2020 CDC WONDER analysis with forecast to 2030

Abstract: Atrial fibrillation (AF) is prevalent in elderly individuals with comorbidities, particularly those with chronic obstructive pulmonary disease (COPD), where their…

Date: 2026-06-23

Pulse pressure and cardiometabolic disease progression: associations with incident multimorbidity and mortality in UK biobank

Abstract: Although pulse pressure (PP) predicts individual cardiometabolic diseases (CMDs), its role in the progression of cardiometabolic multimorbidity (CMM) remains uncertain.…

Date: 2026-06-23

Intradialytic blood pressure instability and associated factors among hemodialysis patients in Somalia: a retrospective study

Abstract: Intradialytic blood pressure (BP) instability—manifesting as intradialytic hypotension (IDH) or hypertension (IDHT)—is increasingly recognized as a contributor to…

Date: 2026-06-23

Ticagrelor plasma concentration, metabolite ratio, and LDH level as independent risk factors for ticagrelor-induced dyspnea in ACS patients

Abstract: Ticagrelor-induced dyspnea is a significant clinical concern and is associated with adverse outcomes. However, the specific risk factors leading to ticagrelor-induced…

Date: 2026-06-23