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HMGB1-TLR4 signaling-mediated neuroinflammation contributes to the pathogenesis of infantile epileptic spasms syndrome in rats

Abstract: Infantile epileptic spasm syndrome (IESS) is a severe age-dependent epileptic encephalopathy in infancy with poor prognosis and unclear pathogenesis. Neuroinflammation…

Date: 2026-06-26

Patient and caregiver perspectives on transition from pediatric to adult care in inborn errors of immunity: a Polish multicenter survey

Abstract: Advances in the diagnosis and treatment of inborn errors of immunity (IEI) have improved survival rates, resulting in a growing population of adolescents requiring…

Date: 2026-06-26

The associations between nailfold microvascular abnormalities and systemic inflammation or Th17/Treg dysregulation in rheumatoid arthritis

Abstract: To investigate the abnormal characteristics of nailfold microcirculation (NMC) in patients with rheumatoid arthritis (RA) and to further analyze the associations between…

Date: 2026-06-26

Immune-dominated cellular heterogeneity and stromal plasticity in keloid infiltrating and hypercellular zones revealed by single-cell RNA sequencing

Abstract: Keloids are aggressive fibroproliferative disorders characterized by a sclerotic core and an actively invading margin, yet the cellular and molecular basis of this…

Date: 2026-06-26

Assessing the multi-software robustness of radiomic biomarkers: a three-tool evaluation

Abstract: To assess the cross-software reproducibility of Computed Tomography (CT) radiomic features extracted using three widely adopted platforms (Siemens syngo.via Frontier, 3D…

Date: 2026-06-26

Navigating specific targets of psychoneurological symptom cluster in breast cancer: a computer-simulated network analysis

Abstract: Sleep disturbance, cancer-related fatigue, emotional distress (anxiety and depression), and pain, collectively known as psychoneurological symptom cluster (PNSC), were…

Date: 2026-06-26

Normal tissue complication probability model of temporal lobe injury following re-irradiation of CIRT for local recurrent nasopharyngeal carcinoma

Abstract: Temporal lobe injury (TLI) is a significant complication after carbon-ion re-irradiation (reRT-CIRT) for locally recurrent nasopharyngeal carcinoma (rNPC). This study…

Date: 2026-06-26

High-density lipoprotein cholesterol levels and prognosis in non-ischemic dilated cardiomyopathy

Abstract: Although low high-density lipoprotein cholesterol (HDL-C) is associated with poor outcomes in heart failure, its specific prognostic role in non-ischemic dilated…

Date: 2026-06-26

Association analysis of weight-adjusted waist index with hypertension and its subtypes

Abstract: Hypertension is a leading global risk factor for cardiovascular diseases, with notable regional differences in China. The weight-adjusted waist index (WWI), a novel…

Date: 2026-06-26

Perioperative mortality and 1-year neurodevelopmental outcome after cardiac surgery prior to 6 weeks of age, requiring perioperative extracorporeal membrane oxygenation in the first year of life

Abstract: Complex congenital heart disease (CHD), neonatal cardiac surgery, and perioperative extracorporeal membrane oxygenation (ECMO) are risk factors for increased…

Date: 2026-06-26