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Application of a posterior tibial artery perforator-based fasciocutaneous flap with a broad fascial pedicle in reconstruction of complex lower-leg wounds: a retrospective clinical study

Abstract: Complex soft-tissue defects of the lower leg with exposed bone, tendon, or internal fixation material remain difficult to reconstruct, particularly when the surrounding…

Date: 2026-06-24

Patterns of morbidity, multimorbidity, and mortality in aging cats: findings from seven years of the Cat Prospective Ageing and Welfare Study

Abstract: Aging is associated with an increased risk of morbidity, multimorbidity and mortality in cats. However, longitudinal cohort studies are somewhat limited in this species.…

Date: 2026-06-24

Assessment of cerebral hemodynamics in patients with acute brain injury: a group-based multivariate trajectory approach

Abstract: This study aimed to describe the evolution patterns of cerebral hemodynamics in acute brain injury (ABI) patients. ABI patients with intracranial pressure (ICP),…

Date: 2026-06-24

Associations between total and regional fat-to-muscle mass ratio and fracture risk in elderly population: a prospective cohort study in UK Biobank

Abstract: Previous studies reported that the overall risk of fragility fractures increased with both obesity (high body mass index, BMI) and sarcopenia (low BMI) in elderly…

Date: 2026-06-24

Comparison of endoscopic plantar fasciotomy and endoscopic partial fascia detachment in patients with chronic plantar fasciitis: a retrospective 1-year follow-up study

Abstract: Plantar fasciitis (PF) is a common disease that causes pain and dysfunction in the heel. Non-surgical treatments of PF can handle most cases, but recurring pain remains…

Date: 2026-06-24

Functional shifts in immune composition follow lactation stage in human milk

Abstract: Human milk contains diverse immune and non-immune cellular components that change dynamically from early to established lactation. We sought to determine if the milk…

Date: 2026-06-24

MicroRNA-383-5p regulation of NADPH oxidase 4 alleviates hemorrhagic transformation and improves acute outcomes after endovascular recanalization in acute ischemic stroke

Abstract: Hemorrhagic transformation (HT) following reperfusion therapy is associated with poor outcomes in patients with acute ischemic stroke. Here, we determined the role of…

Date: 2026-06-24

A nomogram integrating DCE-MRI imaging features and clinicopathological parameters for predicting pathological complete response in HER2-positive breast cancer

Abstract: HER2-positive breast cancer represents approximately 15-20% of all breast cancers and is characterized by aggressive biological behavior. Neoadjuvant chemotherapy (NAC)…

Date: 2026-06-24

Circumferential laryngopharyngectomy with free jejunal transfer for hypopharyngeal cancer: a retrospective cohort analysis of outcomes and complications

Abstract: Hypopharyngeal squamous cell carcinoma (HSCC) is often diagnosed at an advanced stage and characterized by poor prognosis. While primary (chemo)radiotherapy is…

Date: 2026-06-24

Fecal microbiome and metabolome dynamics during immunotherapy-based total neoadjuvant therapy in rectal cancer: associations with treatment response and toxicity

Abstract: Immunotherapy-based total neoadjuvant therapy (iTNT) is a promising strategy for microsatellite-stable locally advanced rectal cancer (LARC), yet therapeutic response…

Date: 2026-06-24