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Dominant T cell receptor clonotypes in adrenocorticotropic hormone-secreting pituitary carcinoma are the highest-frequency clones among CD4 + and CD8 + cells in peripheral blood during effective anti-PD-1 therapy

Abstract: Pituitary carcinoma is a rare and highly aggressive tumor. While anti-programmed cell death-1 (PD-1) therapy has shown efficacy in some cases, the factors that predict a…

Date: 2026-06-15

The exploration and research on the establishment of an early risk assessment system for high-risk diabetic feet

Abstract: To develop an early risk assessment system for high-risk diabetic feet. The system framework was established through literature review and two rounds of Delphi expert…

Date: 2026-06-15

?-cell SLC38A5 supports amino acid-induced ?-cell proliferation and glucagon secretion

Abstract: Pancreatic ? cells are key regulators of glucose homeostasis, and dysregulated glucagon secretion contributes to hyperglycemia in diabetes. Amino acids strongly…

Date: 2026-06-15

Prognostic model for three-year postoperative local recurrence in cutaneous squamous cell carcinoma: a Chinese multicenter cohort study

Abstract: Cutaneous squamous cell carcinoma (cSCC) carries a risk of postoperative local recurrence, with nearly 90% of events occurring within 3 years; however, prognostic tools…

Date: 2026-06-15

Budget impact analysis of energy and nutrient-dense oral nutritional formulas for hospitalized pediatric disease-related malnutrition in the Middle East

Abstract: Disease-related malnutrition is a significant yet underappreciated burden among hospitalized children, particularly in the Middle East, where data on prevalence and…

Date: 2026-06-15

The Ste20 kinase TAOK3 restrains Rac-driven cytoskeletal-mitochondrial coupling to preserve naive CD8 + T cell homeostasis and activation

Abstract: Cytoskeletal remodelling is central to naive T cell fitness, organizing receptor-proximal signaling and mechanotransduction during TCR engagement. However, how…

Date: 2026-06-15

Ischemia-modified albumin in children with clinically suspected acute myocarditis: diagnostic performance and incremental value beyond conventional biomarkers

Abstract: Pediatric acute myocarditis is challenging because presentations range from chest pain to cardiogenic shock, and no single biomarker reflects its inflammatory, ischemic,…

Date: 2026-06-15

Real-world effectiveness and safety of dupilumab therapy in children ?6 years with uncontrolled persistent asthma: a propensity-matched retrospective cohort study

Abstract: Asthma is common in children. Dupilumab is a biological agent that showed effectiveness in older children with uncontrolled asthma; however, its efficacy and safety are…

Date: 2026-06-15

Two-year neurodevelopmental outcome in preterm neonates with cerebral oxygenation monitoring after birth: a multinational, multicenter retrospective follow-up study of the COSGOD III trial

Abstract: During immediate neonatal transition, cerebral tissue oxygen saturation (crSO 2 ) exhibits different behavior compared to peripheral arterial oxygen saturation (SpO 2 ).…

Date: 2026-06-15