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Baseline neutrophil-to-lymphocyte ratio combined with SLEDAI predicts lupus low disease activity state at 1 year: a cohort study

Abstract: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease in which treat-to-target management increasingly emphasizes attainment of Lupus Low Disease…

Date: 2026-06-15

Transdermal entry of a non-pathogenic filamentous fungus Aspergillus oryzae induces an immunomodulatory response in skin-draining lymph nodes

Abstract: The immune response to non-pathogenic fungi entering the skin remains largely unknown. In this study, we focused on the fermentative filamentous fungus Aspergillus…

Date: 2026-06-15

Network analysis identifies core fear symptoms as screening clues for post-PCI rehabilitation in patients with acute myocardial infarction

Abstract: Acute myocardial infarction is a leading cause of death among cardiovascular patients. Fear following percutaneous coronary intervention (PCI) can impede patient…

Date: 2026-06-15

Congestion, but not low cardiac output, is independently associated with acute kidney injury following contrast agent exposure

Abstract: Contrast-associated acute kidney injury (CA-AKI) is frequently associated with adverse outcomes. Renal perfusion gradient is central to glomerular filtration. While…

Date: 2026-06-15

Single-catheter radiofrequency pulmonary vein isolation for atrial fibrillation: a comparative evaluation

Abstract: Circular mapping catheters (CMC) are used to confirm pulmonary vein isolation (PVI) in radiofrequency (RF) ablation for atrial fibrillation (AF), but may be unnecessary…

Date: 2026-06-15

Disease characteristics, treatment, and outcomes in Chinese chronic lymphocytic leukemia patients following BTK inhibitor discontinuation: a multicenter real-world study

Abstract: Utilization of novel Bruton tyrosine kinase inhibitors (BTKi) has become common for treating CLL/SLL patients, yet limited evidence exists on the clinical…

Date: 2026-06-12

Mortality trends in diabetes with proxy-defined steatotic liver disease in the United States, 1999–2023

Abstract: To characterize U.S. mortality trends for diabetes mellitus (DM), proxy-defined metabolic dysfunction–associated steatotic liver disease (MASLD), and deaths listing both…

Date: 2026-06-12

Feminizing hormone therapy using GnRH agonists as antiandrogens is not associated with adverse metabolic and bone effects in adult transgender women

Abstract: Gender-affirming hormone therapy (GAHT) effectively alleviates gender dysphoria. However, its effect on metabolic and bone health is not well-established. The goal of…

Date: 2026-06-12

Development and validation of an interpretable machine learning model for predicting central lymph node metastasis in papillary thyroid cancer

Abstract: To develop and validate a machine learning-based prediction model for central lymph node metastasis (CLNM) in papillary thyroid carcinoma (PTC) patients using routine…

Date: 2026-06-12

A multi-method study on GPs’ perspectives on Lipoprotein(a) as an actionable cardiovascular risk factor

Abstract: Elevated Lipoprotein(a) [Lp(a)] is a common hypercholesterolaemia disorder that requires continuity of care from primary care doctors, yet elevated Lp(a) is a highly…

Date: 2026-06-12