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Heterogeneous immune cell composition in patients with combined immunodeficiency

Abstract: Combined immunodeficiencies (CIDs) are a severe class of inborn errors of immunity characterized by defective T cell development and function, often accompanied by…

Date: 2026-06-12

A federated digital twin reveals cytomegalovirus reactivation impairs CAR-T cell therapy via IL-15-mediated cytokine competition in B-Cell lymphoma

Abstract: Cytomegalovirus (CMV) reactivation occurs in 30 ? 40 % of seropositive patients receiving chimeric antigen receptor T-cell (CAR-T) therapy for B-cell lymphoma and is…

Date: 2026-06-12

Inflammatory biomarker-based prognostic model for immunotherapy outcomes in patients with recurrent or metastatic cervical cancer

Abstract: Conventional predictive biomarkers, including programmed death ligand-1 (PD-L1) expression and tumor mutational burden testing, fail to predict immunotherapy efficacy in…

Date: 2026-06-12

Secondary hemophagocytic lymphohistiocytosis in pediatric patients: a single-center experience

Abstract: Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome. In children, secondary HLH may occur with infection, rheumatologic disease,…

Date: 2026-06-12

Peripheral immune cell subsets as potential predictors of benefit from immune checkpoint blockade therapy in small cell lung cancer

Abstract: Small cell lung cancer (SCLC) is a lethal neoplasia. Chemotherapy (Ct) plus immune checkpoint blockade therapy (ICBt) is now the standard of care although limited…

Date: 2026-06-12

Group painting therapy for children and adolescents with bone tumors: a quasi-experimental trial evaluating anxiety, depression, post-traumatic growth, and health-related quality of life

Abstract: Children and adolescents undergoing treatment for malignant bone tumors frequently experience heightened psychological distress, including anxiety, depression, and…

Date: 2026-06-12

Associations of safe nurse staffing coverage and care complexity factors with nursing-sensitive adverse events in cardiac inpatients: a cross-sectional multicenter study

Abstract: Adverse events (AEs) are linked to nurse staffing levels and care complexity factors; however, evidence in patients hospitalized for cardiac conditions is limited. The…

Date: 2026-06-12

Real-world assessment of low-density lipoprotein cholesterol goal, disease burden and financial burden among patients with atherosclerotic cardiovascular disease in Singapore—A single-centre retrospective cohort study

Abstract: Despite strong evidence supporting intensive low-density lipoprotein cholesterol (LDL-C) lowering in high- and very-high-risk patients to reduce atherosclerotic…

Date: 2026-06-12

One-year outcomes of bioresorbable magnesium scaffold implantation in complex coronary lesions

Abstract: Magmaris is a bioresorbable magnesium scaffold that has shown favorable safety and efficacy in the treatment of de-novo coronary lesions. To report 1-year outcomes after…

Date: 2026-06-12

Effect of remote ischemic preconditioning on the risk of contrast-induced acute kidney injury in patients with coronary heart disease undergoing percutaneous coronary intervention

Abstract: Contrast-induced acute kidney injury (CIAKI) is a frequent and clinically important complication after percutaneous coronary intervention (PCI). Despite standard…

Date: 2026-06-12