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Age-stratified gradients of colorectal neoplasia and an exploratory endoscopic red-flag composite in a lesion-confirmed screening colonoscopy cohort

Abstract: To characterise age-related gradients in colorectal lesion severity and prespecified high-risk endoscopic features in a lesion-confirmed screening colonoscopy cohort and…

Date: 2026-10-02

Helicobacter pylori -induced immune priming requires type I interferon signaling

Abstract: Helicobacter pylori ( H. pylori ) infection induces persistent colonization and chronic inflammation, yet the mechanisms by which bacterial exposure establishes…

Date: 2026-10-02

replicateFest: an R package and shiny app for analysis of T cell receptor repertoire data from the functional expansion

Abstract: The Functional Expansion of Specific T cell (FEST)-based assays combine short-term peptide stimulation with TCR sequencing to identify clonotypes that expand in response…

Date: 2026-10-02

Integrated genome-wide DNA methylation and transcriptomic analysis prioritizes EPHA5 as a candidate non-invasive epigenetic biomarker for oral squamous cell carcinoma

Abstract: Oral squamous cell carcinoma (OSCC) remains a major clinical challenge because of delayed diagnosis and the lack of validated non-invasive biomarkers for OSCC detection.…

Date: 2026-10-02

Perivascular fat attenuation index improves the identification of functional myocardial ischemia beyond traditional risk factors: a coronary CT angiography-derived fractional flow reserve study

Abstract: Perivascular fat attenuation index (FAI) derived from coronary computed tomography angiography (CCTA) is a novel imaging biomarker of coronary inflammation. However, its…

Date: 2026-10-02

Immune and inflammatory features associated with pyroptosis- and myocardial fibrosis-related genes in HFpEF: a machine learning study

Abstract: Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome marked by inflammation, immune dysregulation, and myocardial fibrosis. Whether…

Date: 2026-10-02

The predictive value of glycated CD59 for fetal overgrowth in second-trimester pregnant women

Abstract: To investigate the predictive value of glycated CD59 (gCD59) during mid-pregnancy for adverse pregnancy outcomes, specifically macrosomia and large for gestational age…

Date: 2026-10-01

Association between the cholesterol-high-density lipoprotein-glucose (CHG) index and albuminuria risk in diabetic patients

Abstract: The Cholesterol-High-Density Lipoprotein-Glucose (CHG) index is a novel composite metabolic biomarker. We aimed to evaluate the relationship between the CHG index and…

Date: 2026-10-01

Female hormones enhance skin T cell expansion and suppress IFN-? production

Abstract: Estrogen receptors (ERs) regulate immune function, but their expression across immune cell subsets and hormone responsiveness in human skin are not fully understood. We…

Date: 2026-10-01

Broad systemic T cell immunity to Salmonella enterica serovar Typhi in U.S. healthy adults

Abstract: T cell mediated immunity (T-CMI) is an important component of effective host immunity against intracellular pathogens such as Salmonella enterica serovar Typhi ( S.…

Date: 2026-10-01