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Development and validation of a nomogram model for predicting cardiac autonomic neuropathy in patients with diabetes

Abstract: Diabetic Cardiac Autonomic Neuropathy (DCAN), a critical yet frequently underdiagnosed microvascular complication, is associated with increased mortality. Standard…

Date: 2026-06-05

Metformin attenuates diabetic osteoporosis via the miR-21 mediated Mef2c/Sost pathway

Abstract: ObjectiveThis study aimed to explore the role of the miR-21/Mef2c/Sost pathway in the pathogenesis of diabetic osteoporosis (DOP) and to investigate whether metformin…

Date: 2026-06-05

Non-invasive detection of pediatric atopic dermatitis based on fecal microbiota and metabolite profiles: a diagnostic approach

Abstract: Atopic dermatitis (AD) is a common chronic skin inflammation, which affects 15-20% of children worldwide. Gut microbiota and its metabolites are crucial modulators of…

Date: 2026-06-05

Isolated prenatal foramen ovale closure or restriction presenting after birth: a distinct, under-recognized clinical condition

Abstract: The foramen ovale (FO) plays a central role in fetal circulation. Prenatal FO closure or restriction is well-characterized in fetuses and in neonates with congenital…

Date: 2026-06-05

The impact of antinuclear antibodies and complement levels in the prognosis of pregnant women within the antiphospholipid syndrome spectrum

Abstract: To assess the prevalence and clinical impact of antinuclear antibodies (ANA) and low complement levels on fetal–maternal outcomes in pregnant women within the spectrum…

Date: 2026-06-05

Vaginal dysbiosis and inflammatory signatures in preterm labor: an integrated model for predicting preterm birth

Abstract: Preterm birth (PTB) is a major cause of neonatal morbidity and mortality, with vaginal microbiome dysbiosis and local immune responses implicated in its pathogenesis.…

Date: 2026-06-05

Utility of prenatal trio whole-exome sequencing and methylation-specific multiplex ligation-dependent probe amplification in the evaluation of fetal growth restriction

Abstract: This study aimed to explore the application value of prenatal trio whole-exome sequencing (trio-WES) and methylation-specific multiplex ligation-dependent probe…

Date: 2026-06-05

Postoperative analgesic efficacy of intertransverse process block vs. erector spinae plane block in total laparoscopic hysterectomy: a randomized double-blind trial

Abstract: Due to multiple factors, patients will experience significant postoperative pain following laparoscopic total hysterectomy (TLH), predominantly manifesting as visceral…

Date: 2026-06-05

Single point insulin sensitivity estimator index and incident impaired fasting glucose in Chinese adults: a retrospective cohort study

Abstract: Insulin resistance is the core pathophysiological mechanism underlying the development of impaired fasting glucose (IFG) and diabetes mellitus. The SPISE index is a…

Date: 2026-06-05

Additive impulsivity and emotion dysregulation in adolescents with comorbid bipolar and substance use disorder: a cross-sectional factorial study

Abstract: Comorbid bipolar disorder (BD) and substance use disorder (SUD) in adolescence is associated with poor clinical outcomes, yet the independent and interactive…

Date: 2026-06-05