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Baicalin and valproic acid synergistically induce hepatocellular carcinoma cell apoptosis via ROS-mediated PTEN upregulation

Abstract: The prognosis of liver cancer remains exceedingly poor. The therapeutic potential of baicalin (BAI), a natural bioactive compound, in treating liver cancer is…

Date: 2026-06-03

Clinical exploration of first-line therapy in metastatic lung adenocarcinoma patients with negative or low PD-L1 expression: a retrospective cohort study

Abstract: Either Programmed cell death protein 1 (PD-1)/Programmed cell death-Ligand protein 1 (PD-L1) inhibitors plus chemotherapy or anti-angiogenic agents plus chemotherapy has…

Date: 2026-06-03

Molecular tumor board availability and organization in sarcoma referral centers in Italy: are we on the right track?

Abstract: With the rapid progress of molecular medicine, new target therapies for solid tumors have become available, leading to the creation of molecular tumor boards (MTBs)…

Date: 2026-06-03

Incidence, classification, healing patterns, and vascular remodeling of radial artery dissection assessed by OCT

Abstract: The incidence and natural history of radial artery dissection (RAD) after transradial or distal transradial coronary intervention (TDRI) remain unclear. To determine the…

Date: 2026-06-03

A plasma N-acetyl amino acid panel for type 2 diabetes discrimination built by targeted LC–MS/MS: A case–control study

Abstract: Type 2 diabetes (T2D) is characterized by profound metabolic disturbances, yet clinically actionable biomarkers beyond conventional glycaemic indices remain limited.…

Date: 2026-06-03

Nonlinear association of HbA1c/HDL-C ratio with heart failure in adults: a large cross-sectional study

Abstract: Heart failure (HF) remains a leading cause of morbidity and mortality worldwide. The HbA1c/HDL-C ratio, a novel composite biomarker reflecting glycemic control and lipid…

Date: 2026-06-03

Association between vitamin D deficiency and adrenal gland, kidney function, indicators related to cardiovascular function in hypertensive patients

Abstract: Previous research has established an association between vitamin D deficiency and various non-skeletal metabolic disorders. However, the potential association between…

Date: 2026-06-03

Titin modulation and left ventricular remodelling in chronic primary mitral regurgitation

Abstract: Left ventricular (LV) remodelling in mitral valve prolapse (MVP) is usually induced by chronic mitral regurgitation (MR), however it can also be disproportionate to the…

Date: 2026-06-03

BCL-XL drives fibrotic and leukemic progression in myeloproliferative neoplasms

Abstract: Myeloproliferative neoplasms (MPNs) are frequently accompanied by bone marrow fibrosis and leukemic transformation, yet the cellular and molecular mechanisms that…

Date: 2026-06-02

Effectiveness of a culturally adapted psychoeducational intervention for family caregivers of children with hematologic malignancy: a randomized controlled trial

Abstract: This study aimed to develop and evaluate a culturally adapted psychoeducational intervention to address the severe psychological distress and caregiving burden commonly…

Date: 2026-06-02