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miR-2110 orchestrates ERK–ELK1 transcriptional repression to induce cell-cycle arrest and enhance cytarabine sensitivity in acute myeloid leukemia

Abstract: Acute myeloid leukemia (AML) remains a heterogeneous hematologic malignancy with frequent therapeutic resistance and relapse. Although miR-2110 is upregulated in AML,…

Date: 2026-05-25

Cumulative exposure and patterns of the cholesterol–HDL-C–glucose index and risk of new-onset cardiometabolic multimorbidity: 9-year longitudinal evidence from CHARLS

Abstract: The cholesterol–HDL-C–glucose (CHG) index has been proposed as an integrated marker of glucose–lipid metabolic dysfunction. However, the associations of long-term CHG…

Date: 2026-05-25

Hemoglobin-albumin-lymphocyte-platelet score associated with diabetic foot severity, unlike modified systemic immune-inflammatory index and modified systemic inflammatory response index

Abstract: Accurate evaluation of diabetic foot severity and prompt intervention is expected to improve patient prognosis. Systemic inflammatory response and nutritional metabolic…

Date: 2026-05-25

A clinical investigation using reflectance confocal microscopy to evaluate the add-on efficacy of the Shumin treatment instrument combined with doxycycline for rosacea

Abstract: This study aimed to compare the clinical efficacy and safety of two rosacea treatment regimens: oral doxycycline plus the Shumin treatment instrument and oral…

Date: 2026-05-25

Association between the albumin-to-lymphocyte ratio and short-term mortality in critically Ill pediatric patients: a retrospective cohort study and machine learning analysis

Abstract: Albumin-to-lymphocyte ratio (ALR), integrating nutritional status and immune-inflammatory response, has been proposed as a potential prognostic biomarker in various…

Date: 2026-05-25

Pediatric oncology patients prefer cocoa over oral nutritional supplements in a double-blinded feeding-trial

Abstract: Malnutrition is a common problem during the treatment of pediatric cancer. Therapy-induced taste alterations (dysgeusia) can further exacerbate this and may reduce the…

Date: 2026-05-25

Perceptions of CAH self-management and stress dosing in relation to health-related quality of life as measured by CAHQL

Abstract: Classic congenital adrenal hyperplasia (CAH) requires lifelong glucocorticoid (GC) therapy and the knowledge of how and when to administer GC stress doses to prevent…

Date: 2026-05-25

Non-linear relationship between triglyceride glucose-body mass index and risk of diabetes in adults: a general population-based cohort study of Chinese adults using a publicly available DRYAD dataset

Abstract: Despite triglyceride glucose-body mass index (TyG-BMI) being a validated marker of insulin resistance, its prospective association with diabetes risk remains unclear; we…

Date: 2026-05-25

Application of an artificial-intelligence–based transesophageal echocardiography simulation system in residency training

Abstract: Transesophageal echocardiography (TEE) is a key perioperative monitoring modality in anesthesiology, but traditional training is constrained by limited case exposure,…

Date: 2026-05-25

Factors influencing the sensory profile in patients with autism spectrum disorder from 16 months to 14 years: results of an observational study

Abstract: Sensory processing abnormalities represent a high-impact clinical feature in individuals with Autism Spectrum Disorder (ASD). Sensory alterations can be classified by…

Date: 2026-05-25