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A phase 1 trial of HPV16 E7 T-cell receptor-engineered T cells in patients with relapsed/refractory HPV16-positive cancers (KITE-439 trial)

Abstract: Patients with relapsed/refractory (r/r) HPV-associated epithelial cancers have a poor prognosis. Engineered T cells expressing a T cell receptor (TCR) specific for HPV16…

Date: 2026-05-21

Circulating immune cell profiling in advanced cervical and endometrial cancer patients treated with PD-1 blockade, radiotherapy, and immune modulation in the PRIMMO trial

Abstract: Immune checkpoint blockade (ICB) has revolutionized cancer treatment, including gynecological cancers, yet durable responses are observed only in subsets of patients. To…

Date: 2026-05-21

The instructional modality used for contextual vertical integration of anatomy influences cognitive load and performance during an operative interpretation task in undergraduate gynaecology students: evidence from a multi-centre cluster-randomised controlled trial

Abstract: Operative interpretation is central to the educational value of theatre placements, yet students often struggle to apply preclinical anatomy to the operative setting.…

Date: 2026-05-21

The theory of tumor immuno-ecodynamics

Abstract: In previous studies, I established theoretical frameworks for immunodynamics and tumor ecodynamics, respectively, to quantitatively describe immune responses and the…

Date: 2026-05-21

Multi-omics Mendelian randomization integrating metabolism, microbiome and immunity supports a putative gut-immune-pelvic pathway in deep infiltrating endometriosis

Abstract: Deep infiltrating endometriosis (DIE) is a highly fibrotic and deeply invasive subtype of endometriosis that causes severe pelvic pain, infertility and marked impairment…

Date: 2026-05-21

Conservative management without routine bailout stent for non-flow-limiting dissection after DCB angioplasty: a prospective three-arm study

Abstract: The optimal management of non-flow-limiting coronary dissection after drug-coated balloon (DCB) angioplasty remains controversial, particularly in Asian populations. We…

Date: 2026-05-21

Predictive value of the uric acid-to-albumin ratio for contrast-induced nephropathy after percutaneous coronary intervention and construction of a clinical prediction model in patients with coronary artery disease

Abstract: Percutaneous coronary intervention (PCI) has become the cornerstone of coronary revascularization, and contrast-induced nephropathy (CIN) is one of the most frequent…

Date: 2026-05-21

The association between the C-reactive protein-triglyceride glucose index and myocardial injury after acute ischemic stroke: a machine learning analysis of the brain-heart axis

Abstract: Myocardial injury is a common and serious complication following acute ischemic stroke (AIS), that contributes to poor functional outcomes. The C-reactive…

Date: 2026-05-21

Cathepsin B ablation alleviates VSMC phenotypic switching by modulating alternative macrophage polarization through the NLRP3 signaling pathway

Abstract: The classical activation of pro-inflammatory macrophages contributes to neointimal hyperplasia by driving the excessive accumulation of phenotypically switched vascular…

Date: 2026-05-21

A single-centre real-world study on the application of drug-coated balloons in coronary intervention therapy

Abstract: This study aimed to investigate the real-world experience of drug-coated balloon (DCB) in coronary intervention therapy. This study was a single-center, retrospective…

Date: 2026-05-21