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Melatonin suppresses ILC2-driven airway hyperreactivity via glutathione-dependent metabolic reprogramming

Abstract: Allergic asthma is characterized by type 2 inflammation and overnight worsening of symptoms, yet dynamic fluxes in cellular metabolic profiles driving time-of-day…

Date: 2026-05-11

Expression characteristics of C-reactive protein in autoimmune diseases and their complications

Abstract: Autoimmune diseases involve disruptions in immune tolerance, persistent systemic inflammation, and progressive multi-organ involvement, with increasing global…

Date: 2026-05-11

Clinical and laboratory findings in patients with anti-myelin oligodendrocyte glycoprotein antibodies: experience from two tertiary hospitals in Madrid

Abstract: This study aimed to describe the clinical, radiographic and laboratory characteristics of a cohort of patients diagnosed with anti-myelin oligodendrocyte glycoprotein…

Date: 2026-05-11

Second-order regulation: IFN-? suppresses IL-17A-mediated type 3 inflammation

Abstract: T helper 1 (T H 1) cells often accompany T H 17 cells across diverse tissues in health and disease, including the lungs. However, roles for the T H 1 effector cytokine,…

Date: 2026-05-11

Cisplatin - induced peripheral neuropathy and biomarkers of gut microbial translocation in testicular germ cell tumor survivors

Abstract: Cisplatin-induced peripheral neuropathy (CIPN) is a frequent and often persistent complication in survivors of testicular germ cell tumors (GCT) treated with curative…

Date: 2026-05-11

Interpretable survival modeling integrating nutritional-inflammatory biomarkers in elderly patients with locally advanced esophageal squamous cell carcinoma treated with definitive radiotherapy

Abstract: Elderly patients with locally advanced esophageal squamous cell carcinoma (ESCC) receiving definitive radiotherapy show marked survival heterogeneity. As anatomical…

Date: 2026-05-11

Prognostic value of androgen receptor expression in ER-positive/HER2-negative breast cancer: evidence from a contemporary Chinese cohort

Abstract: The prognostic significance of androgen receptor (AR) expression in ER+/HER2? luminal breast cancer remains controversial, particularly in the context of neoadjuvant…

Date: 2026-05-11

Trends in the diagnosis of variant bladder cancer: a national retrospective cohort analysis

Abstract: The diagnosis of variant bladder cancer (VBC) has significant clinical implications, yet remains a challenge for pathologists and clinicians. Our objective was to…

Date: 2026-05-11

Development and validation of a pre-chemotherapy nomogram integrating systemic immune-inflammation index and prognostic nutritional index to predict severe adjuvant toxicity in colorectal cancer

Abstract: Severe toxicities frequently complicate adjuvant chemotherapy for stage II/III colorectal cancer (CRC), leading to dose reductions and compromised outcomes. While the…

Date: 2026-05-11

Spontaneous coronary artery dissection in an underrepresented region: insights from the Serbian (RS) SCAD registry

Abstract: Evidence on spontaneous coronary artery dissection (SCAD) is largely derived from Western registries, with limited data from Eastern transitional regions. The Serbian…

Date: 2026-05-11