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Melatonin-induced restoration of the intestinal mucosal barrier in inflammatory bowel disease via activation of the SIRT1-LKB1-pAMPK axis

Abstract: Numerous studies indicated inflammatory bowel disease (IBD) patients suffered from sleep disturbances. Although melatonin (MT) exerts positive effects on maintaining…

Date: 2026-05-05

The clinical value of endoscopic ultrasonography combined with endoscopic treatment for upper gastrointestinal lifting lesions

Abstract: The present investigation is designed to assess the synergistic impact of endoscopic ultrasonography (EUS)paired with endoscopic therapy in addressing upper…

Date: 2026-05-05

A comparative analysis of health-related and individual quality of life in people with Parkinson’s disease

Abstract: Quality of life (Qol) results from a complex interplay of physical, mental, and social aspects. Traditional assessments of Qol may not adequately describe well-being in…

Date: 2026-05-05

The novel GLP-1/GIP dual receptor agonist DA5-CH is superior to tirzepatide and exendin-4 in the 6-OHDA Parkinson rat model

Abstract: Parkinson’s disease (PD) is a progressive neurodegenerative disorder for which there is no cure. Diabetes is one of the risk factors for developing PD. Tirzepatide is a…

Date: 2026-05-05

A multimodal machine learning model for predicting postoperative worsening of FOGQ in Parkinson’s disease following STN-DBS

Abstract: To develop and validate a multimodal machine learning model to predict postoperative worsening of freezing of gait questionnaire (FOGQ) scores in patients with…

Date: 2026-05-05

Antigen-specific tolerance and control of autoimmunity effected by liver sinusoidal endothelial cells is unimpaired in liver fibrosis

Abstract: Liver sinusoidal endothelial cells (LSECs) have a key role in maintaining organismal homeostasis by scavenging blood-borne molecules and inducing specific immune…

Date: 2026-05-05

Parenteral neonatal priming followed by heterologous mucosal booster favors IgM + memory B cell induction over systemic plasma cell differentiation

Abstract: Early-life vaccinations often yield short-lived antibody (Ab) responses due to limited germinal center (GC) reaction and plasma cell (PC) survival. The aim of the study…

Date: 2026-05-05

T-cell lymphoma-associated STAT3 variants impose a type 1 regulatory-like phenotype

Abstract: STAT3 signaling is fundamental to T cells, where it underlies basic cellular processes like metabolism and apoptosis, as well as specialized processes like effector…

Date: 2026-05-05

Multiple malignant primary tumors in dogs: an Italian registry-based epidemiological study

Abstract: In human oncology, patients diagnosed with a primary malignant tumor are known to have an increased risk of developing subsequent malignancies. In veterinary medicine,…

Date: 2026-05-05

STC1 promotes colorectal cancer invasion and migration by regulating M2 macrophage polarization via TGF-?1/Smad signaling pathway

Abstract: Colorectal cancer (CRC) mortality is largely attributable to invasion, migration, and an immunosuppressive tumor microenvironment. We examined the clinical relevance and…

Date: 2026-05-05