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Direct-visualization endoscopic retrograde appendicitis therapy for chronic appendicitis with diarrhea: clinical features and outcomes

Abstract: Chronic appendicitis complicated with diarrhea presents diagnostic and therapeutic challenges due to its atypical and prolonged symptoms, often mimicking functional…

Date: 2026-05-01

Clinical efficacy, safety, and predictors of treatment response to SGLT2 versus DPP-4 inhibitors in type 2 diabetes: a retrospective comparative study

Abstract: The prevalence of type 2 diabetes is continuously increasing, and optimizing the treatment strategies for diabetes is an important clinical issue. SGLT2 inhibitors…

Date: 2026-05-01

CFD + CD14 + monocytes: potential pathogenic subset in myasthenia gravis uncovered by multi-omics integration and machine learning analysis

Abstract: Transcriptome?wide association study (TWAS) contributes to discovering novel susceptibility genes related to diseases. Single-cell RNA sequencing (scRNA-seq) has been…

Date: 2026-05-01

Clinical application of HMGB1-TLR4 signaling pathway-mediated neuroinflammatory markers in infantile epileptic spasms syndrome

Abstract: Infantile epileptic spasms syndrome (IESS) is a severe age-specific epileptic encephalopathy with unclear pathogenesis, and neuroinflammation is involved in its…

Date: 2026-05-01

Neurological manifestations in people with HIV in HAART era: a cross-sectional multicenter study

Abstract: The landscape of neurological manifestations of HIV remains unknown after HAART is applied. This study aimed to characterize the spectrum of neurological disorders in…

Date: 2026-05-01

A Chlamydia trachomatis CPAF-STING agonist conjugate vaccine administered intramuscularly and intradermally is immunogenic in the pig model

Abstract: Chlamydia trachomatis ( Ct ) is the most common bacterial cause of sexually transmitted infection worldwide. Given the limited effectiveness of current Ct screening and…

Date: 2026-05-01

Cladribine treatment in pediatric-onset multiple sclerosis: real-world clinical outcomes and safety insights

Abstract: Pediatric-onset multiple sclerosis (POMS) poses unique therapeutic challenges due to high inflammatory activity, early cognitive and psychosocial impact, and…

Date: 2026-05-01

Effects of trimodal prehabilitation on quality of life and negative emotions in patients with advanced triple-negative breast cancer

Abstract: To assess the effectiveness of a four-week trimodal prehabilitation program in enhancing the quality of life, clinical symptoms, and negative emotions of stage IV…

Date: 2026-05-01

Development of an online prediction tool for immunotherapy-related adverse events in patients with advanced NSCLC based on machine learning and temporal validation

Abstract: Despite the widespread use of immune checkpoint inhibitors (ICIs) improving survival outcomes in non-small cell lung cancer (NSCLC) patients, immune-related adverse…

Date: 2026-05-01

Comparative molecular analysis of colorectal cancer in Saudi Arabia: distinct genetic alterations and clinical features

Abstract: Globally, colorectal cancer (CRC) stands as the third most common type of cancer, a ranking that has remained consistent over recent years. However, the scenario…

Date: 2026-05-01