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Zone-specific hepatocytes orchestrate the early onset of host immune defenses during Staphylococcus aureus bloodstream infection

Abstract: Bloodstream infections (BSI) are life-threatening conditions initiated by pathogens entering the circulation, with Staphylococcus aureus among the most lethal causative…

Date: 2026-04-30

Predictive value of peripheral blood eosinophil levels and dynamics for efficacy and safety of immune checkpoint inhibitors in non-small cell lung cancer: a real-world study

Abstract: Heterogeneous benefits from immunotherapy in advanced driver gene–negative non-small cell lung cancer (NSCLC) underscore the need for biomarkers predicting efficacy and…

Date: 2026-04-30

Oncology nutrition care in Indonesia: a cross-sectional survey to characterise practices, barriers and enablers among nutritionists and dietitians

Abstract: Nutrition care is essential for improving oncology treatment outcomes, however evidence on current practices and adherence to the Nutrition Care Process framework in…

Date: 2026-04-30

Clinicopathological landscape and management trends of thyroid carcinoma over two decades: a single-institution study and risk stratification of central lymph node metastasis in T1 papillary thyroid carcinoma

Abstract: This study aimed to describe the clinicopathological landscape of thyroid disease, summarize long-term management trends of thyroid carcinoma (TC) and lymph node…

Date: 2026-04-30

Genomic alterations and dynamic molecular residual disease monitoring predict pathological response to neoadjuvant chemoimmunotherapy in esophageal squamous cell carcinoma

Abstract: Approximately 40-60% of patients with locally advanced esophageal squamous cell carcinoma (ESCC) exhibit suboptimal responses to neoadjuvant chemoimmunotherapy (NCIT),…

Date: 2026-04-30

Seasonal variations in hospital admissions and case-fatality of ischemic stroke: a nationwide analysis of >4.2 million cases in Germany

Abstract: Ischemic stroke is a leading cause of global morbidity and mortality, with seasonal variations potentially influencing both outcomes. While previous studies have…

Date: 2026-04-30

Impact of hypoglycemic regimens on cardiac recovery and quality of life after PCI in elderly AMI patients

Abstract: To investigate the impact of blood glucose control levels on cardiac function recovery and long-term prognosis in elderly patients with acute myocardial infarction (AMI)…

Date: 2026-04-30

Modulating CD38 enzymatic activity during antibody-based immunotherapy in multiple myeloma: a basic science perspective

Abstract: Multiple myeloma (MM) develops within a profoundly immunosuppressive bone marrow (BM) microenvironment. CD38, a multifunctional ectoenzyme highly expressed on malignant…

Date: 2026-04-29

Efficacy and safety analysis of autologous hematopoietic stem cell transplantation for extraocular retinoblastoma

Abstract: This study aimed to assess the efficacy and safety of autologous hematopoietic stem cell transplantation (Auto-HSCT) in pediatric patients with extraocular…

Date: 2026-04-29

Dysregulation of the immune microenvironment in essential thrombocythemia: the interplay of core genes and inflammation-related signaling pathways

Abstract: Essential thrombocythemia (ET) is a myeloproliferative disorder characterized as excessive platelet production. Early and accurate diagnosis is critical to manage the…

Date: 2026-04-29