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Single-cell sequencing reveals dynamic immune features of paraneoplastic pemphigus in a patient with follicular lymphoma

Abstract: Paraneoplastic pemphigus (PNP) is a highly fatal autoimmune blistering disease that commonly occurs in patients with underlying benign or malignant neoplasms. It poses…

Date: 2026-03-18

Cardiorenal risk stratification in high-risk type 2 diabetes using a simple clinical score: findings from the ELIXA trial

Abstract: Early identification of patients with high cardiorenal risk and timely targeted interventions are critical in managing type 2 diabetes (T2D). Although we previously…

Date: 2026-03-18

Impact of testosterone-based gender-affirming hormone therapy on toll-like receptor transcript levels and peripheral blood leukocyte counts in transmasculine individuals

Abstract: Sex differences in immune responses are partly attributed to sex hormones, with testosterone generally associated with dampened immune responses. However, the specific…

Date: 2026-03-18

Effect of a 5:2 intermittent fasting diet on obese patients with polycystic ovary syndrome

Abstract: Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects fertility and metabolism. Obesity, present in a significant proportion of PCOS patients,…

Date: 2026-03-18

Effects of gender-affirming hormone therapy from adolescence to adulthood on cardiovascular function: a cross-sectional study

Abstract: Increased cardiovascular risk in transgender adults might be linked in part to metabolic changes associated with gender-affirming hormone therapy (GAHT) and lifestyle…

Date: 2026-03-18

Clinical and economic impacts of a clinical pathway-based single disease payment policy on hysterectomy for uterine fibroids: a decade-long interrupted time series analysis

Abstract: In 2017, China introduced clinical pathway-based single disease payment (CP-SDP) to curb healthcare costs, yet its impact is uncertain. Using uterine fibroids as a case,…

Date: 2026-03-18

Efficacy comparison of clown care therapy versus virtual reality distraction on venipuncture-induced anxiety in preschool children: a retrospective cohort study

Abstract: Venous blood sampling is a common medical procedure in preschool children that often induces significant anxiety, affecting procedural success and long-term medical…

Date: 2026-03-18

Clinical spectrum and management outcomes of acute febrile illness Among children attending health facilities in northwestern Tanzania, 2020–2021

Abstract: The diagnostic challenges of febrile illness in children in low-resource settings and the risks of empirical overtreatment. We evaluated the range of clinical…

Date: 2026-03-18

Improving screening for antibody deficiency using calculated globulin and serum protein electrophoresis

Abstract: Antibody deficiencies, particularly Common Variable Immunodeficiency (CVID), represent a major health concern due to comorbidities linked to delayed diagnosis.…

Date: 2026-03-18

Implementation of developmental care in routine NICU practice and early clinical outcomes in preterm infants

Abstract: Despite improved survival of preterm infants, neonatal complications and long-term morbidity remain high, highlighting the need for optimized care in neonatal intensive…

Date: 2026-03-18