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Effects of esketamine combined with QLB in older frail patients with colorectal cancer surgery

Abstract: To investigate the effects of esketamine combined with quadratus lumborum block (QLB) on postoperative anxiety, depression, and cognitive function in frail older…

Date: 2026-03-17

Visual prognosis of Behçet’s uveitis patients in China and its associated factors

Abstract: Behçet’s disease (BD) is a chronic, relapsing, multisystem inflammatory disorder, with ocular involvement being a major cause of irreversible visual impairment. Behçet’s…

Date: 2026-03-17

GeneCytNet: an interpretable deep learning framework for rheumatoid arthritis classification and in silico cytokine perturbation modeling

Abstract: Rheumatoid arthritis (RA) is a heterogeneous autoimmune disease where cytokine-driven dysregulation of gene networks poses a significant challenge for accurate diagnosis…

Date: 2026-03-17

Effects of meteorological variability on the burden of musculoskeletal disorders among people aged 55 and above in the United States: a secondary analysis of the Global Burden of Disease Study 2021

Abstract: Older adults in high-income countries face an increasing burden of musculoskeletal (MSK) disorders. Although the belief that meteorological variations influence…

Date: 2026-03-17

Development and interpretable machine learning models for classification of pancreatic pseudocyst risk in acute pancreatitis

Abstract: Pancreatic pseudocysts (PPC) are a late local complication of acute pancreatitis (AP). Persistent PPC carry a high risk of severe outcomes. Existing models, which are…

Date: 2026-03-17

A cell line–derived, immune-competent neurospheroid model to study neuroinflammation and human brain disorders

Abstract: Three-dimensional (3D) human brain models have become indispensable tools to investigate neuroimmune interactions and inflammatory processes in the human central nervous…

Date: 2026-03-17

Acyl-CoA synthetase long-chain family member 4—A novel prognostic marker in cutaneous melanoma

Abstract: Ferroptosis is an iron-dependent form of regulated cell death driven by lipid peroxidation. Acyl coenzyme A (Acyl-CoA) synthetase long-chain family member 4 (ACSL4)…

Date: 2026-03-16

The mediating role of sleep quality in the association between inflammatory disease activity and health-related quality of life in rheumatoid arthritis

Abstract: Sleep disturbance is highly prevalent in rheumatoid arthritis (RA) and is a key determinant of patient-reported outcomes. However, the mechanistic pathways linking…

Date: 2026-03-16

Elevated stress hyperglycemia ratio predicts intensive care unit admission after surgery for gastrointestinal tumors: an INSPIRE database analysis

Abstract: Gastrointestinal tumors are a major global health burden, with surgery as the main curative treatment. The Stress Hyperglycemia Ratio (SHR) has prognostic value in…

Date: 2026-03-16

The impact of liposomal bupivacaine erector spinae plane block on postoperative analgesia and early functional recovery in patients undergoing thoracoscopic lung cancer surgery

Abstract: This study aimed to evaluate the impact of liposomal bupivacaine erector spinae plane block (ESPB) on postoperative analgesia and early functional recovery in patients…

Date: 2026-03-16