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Single-nucleus and spatial transcriptomics reveal intestinal cellular heterogeneity, differentiation, and cell communication mechanisms in SAP-induced intestinal injury

Abstract: Acute pancreatitis (AP) ranges from mild to severe, and severe disease frequently causes multi-organ damage, with intestinal injury being a major complication. The…

Date: 2026-01-30

Evaluation of the classification performance and cost-effectiveness of classification criteria in children with systemic lupus erythematosus

Abstract: Childhood-onset systemic lupus erythematosus (cSLE) is a chronic autoimmune disease. In Latin America, the utility of the existing lupus classification criteria and…

Date: 2026-01-30

Uridine diphosphate drives myeloid differentiation and functional reprogramming through dynamic transcriptional network

Abstract: Extracellular nucleotides regulate immune responses through purinergic signaling. Uridine diphosphate (UDP), a pyrimidine-derived metabolite, has been shown to…

Date: 2026-01-30

Efficacy and safety of Ixazomib-based maintenance therapy after autologous hematopoietic stem cell transplantation in multiple myeloma patients: a retrospective analysis

Abstract: The therapeutic standard for post-autologous stem cell transplantation (ASCT) maintenance in multiple myeloma (MM) is evolving, with daratumumab-based regimens emerging…

Date: 2026-01-29

Long-term cellular and humoral responses to SARS-CoV-2 vaccinations in patients with solid malignancies undergoing chemotherapy

Abstract: While SARS-CoV-2 vaccines are highly effective in healthy individuals, the magnitude and durability of humoral and cellular responses in patients with solid malignancies…

Date: 2026-01-29

A novel immune model predicts the prognosis of mantle cell lymphoma

Abstract: Mantle Cell Lymphoma (MCL) is a subtype of B-cell lymphoma characterized by varied clinical manifestations. The immune status is associated with MCL’s development and…

Date: 2026-01-29

Exosomal ANGPTL2 in cerebrospinal fluid as a novel prognostic biomarker for primary central nervous system lymphoma

Abstract: Angiopoietin-like protein 2 (ANGPTL2) functions as a key pro-tumorigenic mediator in the tumor microenvironment. While liquid biopsies using exosomal proteins to reflect…

Date: 2026-01-29

Clinical characteristics and prognosis of immunoglobulin light chain amyloidosis patients

Abstract: To analyze the prognostic factors associated with overall survival (OS) in patients diagnosed with immunoglobulin light chain (AL) amyloidosis, with the goal of…

Date: 2026-01-29

Single-cell analysis reveals the cellular and transcriptional heterogeneity of the normal pediatric thyroid

Abstract: To enhance the understanding of cellular heterogeneity within the pediatric thyroid, single-nuclei RNA sequencing was used to recover 38,069 non-pathogenic cells from…

Date: 2026-01-29

Identification of two novel MVD mutations and one novel FDPS mutation in Chinese patients with porokeratosis

Abstract: Porokeratosis (PK) is an autosomal dominant inherited disorder characterized by abnormal epidermal keratinization, primarily resulting from mutations in four genes…

Date: 2026-01-29