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Investigating the causal role of cellular senescence-related genes in preeclampsia: a multi-omics Mendelian randomization study with differential expression analysis

Abstract: The causal role of cellular senescence in preeclampsia pathogenesis is not fully established. This study aimed to systematically prioritize key senescence-related genes…

Date: 2025-10-27

Perinatal outcomes of spontaneous single fetal death in monochorionic twin pregnancies: a single-center retrospective study

Abstract: The aim of this study was to investigate the perinatal outcomes of surviving co-twins after spontaneous single intrauterine fetal death (sIUFD) in monochorionic (MC)…

Date: 2025-10-27

Predictive model of sperm DNA fragmentation in infertile men based on lifestyle factors

Abstract: This study aimed to investigate the influence of lifestyle factors on the sperm DNA fragmentation index (DFI) in infertile men, and to develop and validate a predictive…

Date: 2025-10-27

Temperament correlates of stigma resistance among patients with mood disorders: a cross-sectional study

Abstract: In the realm of mental health, stigma presents a barrier to well-being and social acceptance. However, amidst societal prejudices, stigma resistance emerges as a vital…

Date: 2025-10-27

A prospective pilot study on plasma amyloid beta oligomers and postoperative delirium

Abstract: Postoperative delirium (POD) is common in older adults and has been linked to Alzheimer’s disease (AD). Plasma amyloid-? oligomers (A?Os) may clarify this relationship.…

Date: 2025-10-27

AI-assisted peripheral immune profiling reveals unconventional lymphocyte signatures associated with prognosis in soft tissue sarcoma patients

Abstract: Immunotherapy has reshaped the treatment of several cancers, yet patient responses remain highly variable, partly due to differences in immune competence. In soft tissue…

Date: 2025-10-27

Stepwise development of an implementation protocol to support the prescription of Exercise?=?Medicine by clinicians using the Implementation Mapping approach

Abstract: Several barriers, such as lack of time, knowledge and support, hinder clinicians from providing an individually tailored physical activity (PA) prescription and referral…

Date: 2025-10-27

Association between CT-derived skeletal muscle and fat indices and fracture healing following operative treatment for intertrochanteric fractures: a multicenter retrospective study

Abstract: Intertrochanteric fractures account for nearly 50% of hip fractures in elderly patients and are primarily treated with internal fixation. Considerable variability in…

Date: 2025-10-27

Artemisia absinthium L. ethanol extract inhibits the growth of gastrointestinal cancer cells by inducing apoptosis and mitochondria-dependent pathway

Abstract: Artemisia absinthium L. has a long history in the treatment of gastrointestinal cancer (GIC), but its molecular mechanisms remain unclear. We identified and validated…

Date: 2025-10-27

Retrospective analysis of 11 patients with ipsilateral hemiplegia caused by acute cerebral infarction

Abstract: To summarize the clinical and imaging characteristics of patients with ipsilateral hemiparesis caused by acute cerebral infarction, and to explore possible…

Date: 2025-10-27