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Mutation of conserved MHC class I cytoplasmic tyrosine affects CD8+ T cell priming, effector function, and memory response

Abstract: The cytoplasmic domain of MHC class I (MHC-I) molecules contains a single, highly conserved tyrosine residue (Y320). In previous work, we found that mice expressing a…

Date: 2025-09-30

Urinary quality of life in patients treated with prostate SBRT with intra-prostatic boost

Abstract: SBRT is a standard of care treatment for localized prostate cancer. Whole gland dose escalation remains controversial. Concomitant intraprostatic boost (IPB) may offer…

Date: 2025-09-30

Addressing sexual health needs in gynecological cancer survivors: insights from a tertiary cancer center in Jordan

Abstract: Sexual health is a crucial aspect of quality of life, yet it is rarely addressed by healthcare providers, especially in the context of gynecological cancer. Reports on…

Date: 2025-09-30

Signaling intact membrane-bound IL-15 enables potent anti-tumor activity and safety of CAR-NK cells

Abstract: Chimeric antigen receptor (CAR)-NK cells are a promising and safe alternative to CAR-T cells. However, the limited persistence in vivo restricts their clinical…

Date: 2025-09-30

Perforator mapping for head and neck reconstructive surgery: a novel personalized approach using magnetic resonance angiography based 3D models and 3D-printing

Abstract: Reconstruction of large head and neck defects in oncologic patients often requires free vascularized tissue flaps. Successful flap design and elevation depend on…

Date: 2025-09-30

Immunotherapy combined with definitive chemoradiotherapy for locally advanced unresectable esophageal squamous cell carcinoma

Abstract: The clinical value of immune checkpoint inhibitors (ICIs) in the treatment of unresectable locally advanced esophageal squamous cell carcinoma (LA-ESCC) remains under…

Date: 2025-09-30

Spectrum of care approach to animal shelter management of feline infectious peritonitis complicated by feline leukemia virus

Abstract: Feline infectious peritonitis (FIP) occurs most commonly in multi-cat environments such as animal shelters. FIP is often suspected based on compatible history,…

Date: 2025-09-29

Lithospermum erythrorhizon extract alleviates immunosuppression via MAPK signaling pathway

Abstract: Lithospermum erythrorhizon extract (LEE), rich in shikonin and its derivatives, has been traditionally valued for anti-inflammatory and wound-healing properties. This…

Date: 2025-09-29

Environmental noise and self-rated health in older surgical patients undergoing general anesthesia: a cross-sectional study of anxiety as a behavioral pathway for healthy aging

Abstract: Promoting healthy aging—a core public-health objective—demands hospital environments that support functional recovery and well-being. Excessive ward noise, however, is a…

Date: 2025-09-29

Electroencephalogram prediction of propofol effects on neuromodulation in disorders of consciousness

Abstract: This study aimed to characterize electroencephalogram (EEG) responses to low-dose propofol anesthesia in patients with disorders of consciousness (DoC) of distinct…

Date: 2025-09-29