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Dosimetric parameter determination of a carbon-nanotube based miniature x-ray tube for HDR brachytherapy

Abstract: This study aims to determine key dosimetric parameters of a vacuum-sealed miniature X-ray tube (mXT) equipped with a carbon nanotube field emitter for application in HDR…

Date: 2025-11-19

Establishment and validation of a prognostic model for nasopharyngeal carcinoma patients based on partial response rates

Abstract: This study aims to investigate the impact of varying rates of partial response (PR) on survival outcomes in nasopharyngeal carcinoma (NPC) patients following induction…

Date: 2025-11-19

Oligocentric Castleman disease: clinical characteristics and surgical outcomes from a single-centre retrospective study

Abstract: Oligocentric Castleman Disease (OCD), a distinct subtype of Castleman Disease (CD) intermediate between Unicentric (UCD) and idiopathic Multicentric (iMCD) forms,…

Date: 2025-11-19

Pan-cancer landscape of UBD/FAT10 and experimental validation in esophageal carcinoma

Abstract: To comprehensively characterize the pan-cancer roles of Ubiquitin D (UBD/FAT10) in tumorigenesis, immune regulation, and therapeutic response through integrative…

Date: 2025-11-19

The prognostic value of pretreatment inflammatory and nutrition-related indices in patients with cardia cancer

Abstract: To evaluate the prognostic significance of inflammatory and nutrition-related indexes in patients with cardia cancer prior to treatment. A total of 229 patients with…

Date: 2025-11-19

A novel CTLA-4 deletion variant in a child with refractory autoimmune hemolytic anemia: molecular and functional characterization

Abstract: As a critical immune checkpoint, cytotoxic T-lymphocyte-associated protein 4( CTLA-4 )deficiency is a well-established cause of inborn errors of immunity. This study…

Date: 2025-11-19

CldU sensitizes BRCA2 reverse-mutated cells to PARP inhibitors

Abstract: PARP inhibitors are widely used class of drugs for the treatment of homologous recombination deficient cancers, including BRCA mutated ones. These drugs led to…

Date: 2025-11-19

Higher prevalence of short stature and excess weight in children with sleep disorders

Abstract: Sleep disorders are common in childhood and are recognized as a significant public health concern, particularly due to their association with childhood obesity. However,…

Date: 2025-11-19

The impact of a value-based hospital-community-family linkage program on blood glucose management and hypoglycemia in elderly diabetic patients: a randomized controlled trial

Abstract: The management of elderly type 2 diabetes (T2DM) presents significant challenges, with the risk of hypoglycemia being particularly prominent. This risk severely impacts…

Date: 2025-11-19

Morning spot urinary cortisol-to-creatinine ratio: a novel screening tool for assessing excess cortisol secretion

Abstract: Current screening methods for hypercortisolism face limitations in clinical practice. Our study proposes and validates a novel biomarker, the morning spot urinary…

Date: 2025-11-19