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Yes-associated protein regulates autophagy to restore skin barrier function in atopic dermatitis

Abstract: Atopic dermatitis (AD) is characterized by skin barrier dysfunction and inflammation.This study explored the relationship between Yes-associated protein (YAP)…

Date: 2025-11-19

Beyond the skin: immunological profiles and infectious complications in ALOX12B-associated autosomal recessive congenital ichthyosis

Abstract: Pathogenic variants in ALOX12B , a crucial enzyme involved in epidermal lipid processing, are among the most common causes of autosomal recessive congenital ichthyosis…

Date: 2025-11-19

Neuromedin B identified as a therapeutic target for atopic dermatitis: evidence from Mendelian randomization and PCR validation

Abstract: Atopic dermatitis (AD) is a long-standing inflammatory dermatosis marked by intense itching and immune imbalance. Despite recent advances in targeted biologic therapies,…

Date: 2025-11-19

CIK-augmented anti-PD1/CTLA4 immunotherapy eradicates chemo-resistant ovarian cancer via tripartite mechanistic synergy

Abstract: Immune checkpoint inhibitors (ICIs) combined with adoptive cell therapy represent promising strategies against ovarian cancer, yet their synergistic mechanisms remain…

Date: 2025-11-19

Impact of smoking exposure on meibomian gland morphology and tear film stability: a cross-sectional study

Abstract: To investigate the effects of smoking on the structure and function of the meibomian glands. A total of 104 chronic smokers (with a smoking history of more than 5?years)…

Date: 2025-11-19

Financial barriers for medical students attending ophthalmology conferences: an analysis of registration fees

Abstract: Ophthalmology conferences are vital for knowledge exchange, networking, and professional development in ophthalmology. However, financial barriers may limit medical…

Date: 2025-11-19

Associations between metabolic-inflammatory biomarkers and Helicobacter pylori infection: an interpretable machine learning prediction approach

Abstract: This study investigated the association between metabolic-inflammatory markers and Helicobacter pylori (HP) infection using interpretable machine learning models, with a…

Date: 2025-11-19

Construction and validation of a transmembrane 4 superfamily-related genes prognostic model for esophageal squamous cell carcinoma

Abstract: Esophageal squamous cell carcinoma (ESCC), a virulent form of cancer, markedly diminishes prospects for patient survival. The transmembrane 4 superfamily ( TM4SF…

Date: 2025-11-19

The impact of frailty on cognitive outcomes in elderly patients with post-stroke subjective cognitive complaints

Abstract: Frailty delineates a state of poor health characterized by the accumulation of age-related health deficits, and was associated with cognitive decline in patients with…

Date: 2025-11-19

Levodopa/carbidopa/entacapone versus levodopa/benserazide plus pramipexole in Chinese patients with Parkinson’s disease experiencing wearing off

Abstract: To compare the efficacy and safety of direct switch from levodopa/benserazide (LB) to levodopa/carbidopa/entacapone (LCE) versus LB plus pramipexole (PPX) in Chinese…

Date: 2025-11-19