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Accelerating rare disease detection: an experience of multidisciplinary team model in undiagnosed diseases program in a children’s hospital

Abstract: Background: A definite diagnosis goes undiscovered for a percentage of children with undiagnosed disorders, with significant medical, psychological, and social effects.…

Date: 2024-09-17

Network pharmacology and molecular docking approach to elucidate the mechanisms of safflower, phellodendron, scutellaria baicalensis, coptis, and gardenia in hand–foot syndrome

Abstract: Background: Safflower, phellodendron, scutellaria baicalensis, coptis, and gardenia (SPSCG) are medicinal plants with a wide range of anti-inflammatory and antioxidant…

Date: 2024-09-16

A nomogram with Nottingham prognostic index for predicting locoregional recurrence in breast cancer patients

Abstract: Background: The Nottingham prognostic index (NPI) has been shown to negatively impact survival in breast cancer (BC). However, its ability to predict the locoregional…

Date: 2024-09-16

Survival benefits of radiotherapy in locally advanced unresectable and metastatic pancreatic cancer: a single-institution cohort and SEER database analysis

Abstract: Background: Chemotherapy (CT) remains the primary treatment for locally advanced unresectable pancreatic cancer (LAUPC) and metastatic pancreatic cancer (MPC). The role…

Date: 2024-09-16

Survival outcomes in patients with de novo metastatic Merkel cell carcinoma according to site of metastases

Abstract: Introduction: Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine malignancy of the skin with a predilection for metastases. This study investigates the…

Date: 2024-09-16

Volumetric modulated arc therapy total body irradiation improves toxicity outcomes compared to 2D total body irradiation

Abstract: Introduction: Volumetric modulated arc therapy (VMAT) total body irradiation (TBI) allows for greater organ sparing with improved target coverage compared to 2D-TBI.…

Date: 2024-09-16

Identification of common signature genes and pathways underlying the pathogenesis association between nonalcoholic fatty liver disease and heart failure

Abstract: Background: Non-alcoholic fatty liver disease (NAFLD) and heart failure (HF) are related conditions with an increasing incidence. However, the mechanism underlying their…

Date: 2024-09-16

Efficacy and safety of switching to bilastine, an H1-antihistamine, in patients with refractory chronic spontaneous urticaria (H1-SWITCH): a multicenter, open-label, randomized, parallel-group comparative study

Abstract: Background: For treating patients with refractory chronic spontaneous urticaria (CSU) resistant to standard doses of 2nd generation H1-antihistamines (H1AH) the…

Date: 2024-09-16

Utilize proteomic analysis to identify potential therapeutic targets for combating sepsis and sepsis-related death

Abstract: Background: Sepsis is an inflammatory disease that leads to severe mortality, highlighting the urgent need to identify new therapeutic strategies for sepsis. Proteomic…

Date: 2024-09-16