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Efficacy and safety of Ixazomib-based maintenance therapy after autologous hematopoietic stem cell transplantation in multiple myeloma patients: a retrospective analysis

Abstract: The therapeutic standard for post-autologous stem cell transplantation (ASCT) maintenance in multiple myeloma (MM) is evolving, with daratumumab-based regimens emerging…

Date: 2026-01-29

Long-term cellular and humoral responses to SARS-CoV-2 vaccinations in patients with solid malignancies undergoing chemotherapy

Abstract: While SARS-CoV-2 vaccines are highly effective in healthy individuals, the magnitude and durability of humoral and cellular responses in patients with solid malignancies…

Date: 2026-01-29

A novel immune model predicts the prognosis of mantle cell lymphoma

Abstract: Mantle Cell Lymphoma (MCL) is a subtype of B-cell lymphoma characterized by varied clinical manifestations. The immune status is associated with MCL’s development and…

Date: 2026-01-29

Exosomal ANGPTL2 in cerebrospinal fluid as a novel prognostic biomarker for primary central nervous system lymphoma

Abstract: Angiopoietin-like protein 2 (ANGPTL2) functions as a key pro-tumorigenic mediator in the tumor microenvironment. While liquid biopsies using exosomal proteins to reflect…

Date: 2026-01-29

Clinical characteristics and prognosis of immunoglobulin light chain amyloidosis patients

Abstract: To analyze the prognostic factors associated with overall survival (OS) in patients diagnosed with immunoglobulin light chain (AL) amyloidosis, with the goal of…

Date: 2026-01-29

Single-cell analysis reveals the cellular and transcriptional heterogeneity of the normal pediatric thyroid

Abstract: To enhance the understanding of cellular heterogeneity within the pediatric thyroid, single-nuclei RNA sequencing was used to recover 38,069 non-pathogenic cells from…

Date: 2026-01-29

Identification of two novel MVD mutations and one novel FDPS mutation in Chinese patients with porokeratosis

Abstract: Porokeratosis (PK) is an autosomal dominant inherited disorder characterized by abnormal epidermal keratinization, primarily resulting from mutations in four genes…

Date: 2026-01-29

Standardized pressure provocation as an objective clinical marker of omalizumab response in delayed pressure urticaria: an open-label, real-life, prospective cohort

Abstract: Delayed pressure urticaria (DPU) is a disabling chronic inducible urticaria characterized by delayed painful swelling after sustained pressure. Evidence-based…

Date: 2026-01-29

Co-exposure to lead and cadmium is associated with increased severity of social deficits in children with autism spectrum disorders

Abstract: This case–control study aimed to compare micronutrient (vitamins and minerals) profiles between children with autism spectrum disorders (ASD) and age- and gender-matched…

Date: 2026-01-29

Epidemiological profile of acquired syphilis in children and adolescents in Brazil: a nationwide observational study

Abstract: Acquired syphilis, which is historically considered a condition with almost exclusive prevalence in adults, has shown, in recent evidence, an alarming increase amongst…

Date: 2026-01-29