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Post-licensure safety surveillance of 9-valent human papillomavirus vaccine using the vaccine adverse event reporting system, 2014–2024

Abstract: On December 10, 2014, the Food and Drug Administration (FDA) licensed the 9-valent human papillomavirus vaccine (9vHPV) for prevention of HPV-related cancers and genital…

Date: 2026-01-20

Association between iron deficiency anemia and the risk of new-onset tuberculosis infection: a matched cohort analysis

Abstract: Tuberculosis remains a major global health challenge, with emerging evidence suggesting that micronutrient deficiencies may contribute to susceptibility to infection…

Date: 2026-01-20

Associations of eosinophil-to-monocyte ratio and C-reactive protein-to-high-density lipoprotein cholesterol ratio with early neurological deterioration after thrombolysis in acute ischemic stroke

Abstract: Inflammation mechanisms play critical roles in acute ischemic stroke (AIS). However, the correlations of the eosinophil-to-monocyte ratio (EMR) and blood C-reactive…

Date: 2026-01-20

Development and comparison of multivariate diagnostic models for rapidly progressive central precocious puberty in girls: the role of serum osteocalcin

Abstract: To develop a diagnostic prediction model for rapidly progressive central precocious puberty (RP-CPP) and evaluate the contribution of osteocalcin(OC) to the model. For a…

Date: 2026-01-19

Comparison of endovascular treatment outcomes in stroke patients with cardioembolic or intracranial atherosclerosis-predisposed large vessel occlusion

Abstract: The benefit of endovascular treatment (EVT) in patients with acute ischemic stroke due to large vessel occlusion is now well established. EVT is highly effective for…

Date: 2026-01-19

Admission NIHSS score and diabetes as independent predictors of in-hospital early neurological improvement following mechanical thrombectomy: a retrospective cohort study

Abstract: Accurate early prognostication in acute ischemic stroke (AIS) is essential for optimizing post-thrombectomy management strategies. However, the predictive utility of…

Date: 2026-01-19

Impact of treatment interruption on the efficacy and safety of vunakizumab in patients with moderate-to-severe plaque psoriasis: a post-hoc analysis of a phase 3 trial

Abstract: Vunakizumab, a novel IL-17A inhibitor, has demonstrated satisfactory efficacy and safety for the treatment of moderate-to-severe plaque psoriasis. This analysis aimed to…

Date: 2026-01-16

Sibling-controlled study of the impact of dietary therapy on the gut microbiota in children with phenylketonuria

Abstract: Phenylketonuria (PKU) is an autosomal recessive metabolic disorder caused by a deficiency of phenylalanine hydroxylase activity. Due to intolerance to the dietary intake…

Date: 2026-01-16

Real-world effectiveness of SGLT2 inhibitors in patients with HF and ESKD: a multicenter cohort study

Abstract: Patients with heart failure (HF) and end-stage kidney disease (ESKD) face a high burden of mortality and hospitalization, yet effective therapeutic options remain…

Date: 2026-01-16

Effect of tidal volume on gastric insufflation during laparoscopic cholecystectomy: a strictly retrospective observational study

Abstract: Laparoscopic cholecystectomy (LC) is the gold-standard minimally invasive gallbladder removal procedure. Optimal ventilation during LC requires positive end-expiratory…

Date: 2026-01-16