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Integrated bulk and single-cell transcriptomics unveil the role of AHCY in cell cycle regulation of endometrial cancer

Abstract: Although AHCY has been implicated in cancer progression, its specific role in endometrial cancer (EC) remains poorly understood. This study aimed to elucidate the…

Date: 2026-08-20

Shared Treg dysregulation underlies psoriasis vulgaris and atopic dermatitis through the PHF19-PRC2 epigenetic axis

Abstract: Psoriasis vulgaris (PV) and atopic dermatitis (AD) are chronic inflammatory skin diseases characterized by distinct dominant T cell subsets, yet emerging evidence…

Date: 2026-08-20

Integrated bioinformatics analysis reveals convergent molecular signatures associated with SERPINB7 and SERPINA12 deficiency

Abstract: Pathogenic variants in SERPINA12 have recently been identified in patients with palmoplantar keratoderma (PPK). Clinically, SERPINA12-associated PPK shares substantial…

Date: 2026-08-20

Establishment of an antepartum predictive model for postpartum hemorrhage in preterm delivery: a retrospective matched case-control study

Abstract: Postpartum hemorrhage (PPH) occupies a prominent position among severe maternal morbidity (SMM) in preterm pregnancies, yet current research on predicting PPH in preterm…

Date: 2026-08-20

Clinical and epidemiological profiles of six respiratory pathogens in hospitalized children in Lixin County, Anhui, China (2024–2025)

Abstract: Acute respiratory infections are caused by a diverse range of pathogens. This study aimed to investigate the epidemiological profiles and clinical features of major…

Date: 2026-08-20

Digitalization of medical and healthcare education in a Low- and middle-income country: a mixed-method case study of institutional transformation at Yerevan State Medical University

Abstract: Digitalizing healthcare professionals' education for the future is essential to ensure the availability of skilled medical professionals across settings, particularly in…

Date: 2026-08-20

Anti-PAR2 autoantibodies are associated with chronic histological injury in kidney transplant recipients

Abstract: Non-HLA autoantibodies directed against G protein-coupled receptors (GPCRs) have emerged as potential contributors to endothelial activation, vascular injury, rejection,…

Date: 2026-08-20

Machine learning-based identification of anxiety symptoms in Chinese community-dwelling older adults: a comparative study of six algorithms with SHAP analysis and nomogram development

Abstract: Anxiety disorders are common among older adults but remain underrecognized in community settings, particularly in China where mental health resources are scarce. This…

Date: 2026-08-20

Development and preliminary psychometric evaluation of the vaginal douching practice scale

Abstract: Vaginal douching remains common in several settings despite its association with adverse reproductive health outcomes. A standardized instrument for assessing how…

Date: 2026-08-20

Ageism, ableism, and their associated factors among international undergraduate medical students in China: a cross-sectional study

Abstract: Ageism and ableism are common attitudes that have significant effects on the quality of healthcare provided to older adults and people with impairments. Despite growing…

Date: 2026-08-20