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Exploring the impact of DEP on pediatric Crohn's disease using machine learning and molecular docking methods

Abstract: Diethyl phthalate (DEP) is a prevalent plasticizer with multiple toxic effects and high bioavailability in humans, especially children. Pediatric Crohn’s disease (PCD)…

Date: 2026-08-18

Initiating multi-strain probiotics is associated with clinically meaningful symptom relief, better quality of life, and fewer treatment escalations in IBS-D/IBS-M: a Chinese real-world propensity-matched cohort study

Abstract: Evidence for probiotics in irritable bowel syndrome remains heterogeneous, although real-world use is common in Chinese gastroenterology practice. This study evaluated…

Date: 2026-08-18

Single-cell transcriptomic profile unveils distinct immune ecosystems in alcohol- and nonalcohol-associated hepatocellular carcinoma

Abstract: Alcohol-associated hepatocellular carcinoma (A-HCC) shows more aggressive progression and has a poorer prognosis than nonalcohol-associated HCC (NA-HCC), but the…

Date: 2026-08-18

Analysis of differences between early-onset and late-onset early gastric cancer treated with endoscopic submucosal dissection

Abstract: Gastric cancer is one of the most common cancers worldwide, with high incidence and mortality rates. The aim of this study was to analyze the differences in…

Date: 2026-08-18

Enteral feeding tube use among pediatric patients and nurses’ knowledge in China: a 52-hospital point-prevalence and cross-sectional survey study

Abstract: Enteral feeding tubes are widely used in pediatric patients, but tube-related complications remain a safety concern. Understanding current practice and nurses’ knowledge…

Date: 2026-08-18

Increased serum fibroblast growth factor 2 levels, altered peripheral blood inflammatory indicators and their ratios in amyotrophic lateral sclerosis: a clinical exploratory study

Abstract: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by motor neuron degeneration, leading to muscle weakness, atrophy, and…

Date: 2026-08-18

Genetically defined systemic autoinflammatory diseases in pediatric patients with Behçet’s disease

Abstract: The aim of this study was to characterize the genetic basis of Behçet’s disease (BD) and mimics in a pediatric cohort. We retrospectively studied 34 patients of…

Date: 2026-08-18

Efficacy and safety of zoledronic acid versus denosumab in the treatment of primary osteoporosis: a single-center retrospective cohort study

Abstract: To compare the long-term efficacy and safety of zoledronic acid versus denosumab in the treatment of primary osteoporosis. This retrospective cohort study analyzed 328…

Date: 2026-08-18

Ruxolitinib for rheumatic disease-associated macrophage activation syndrome in children: a retrospective cohort study

Abstract: Macrophage activation syndrome (MAS) is a severe, life-threatening complication in pediatric rheumatic diseases. Current treatments are predominantly based on…

Date: 2026-08-18

Acute hypersensitivity reactions to paclitaxel polymeric micelles during malignant tumor treatment: a retrospective real-world study

Abstract: Paclitaxel polymeric micelles (pm-Pac) are widely used for solid tumors, but real-world data on acute hypersensitivity reactions (HSRs) are limited. This exploratory…

Date: 2026-08-18