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Real-world efficacy and safety profile of low-dose cadonilimab in recurrent or metastatic cervical cancer as first-line therapy

Abstract: Cadonilimab, a bispecific PD-1/CTLA-4 antibody, has activity in recurrent/metastatic cervical cancer (R/M CC), but high costs limit accessibility, especially in low- and…

Date: 2026-08-18

AMPK–PP1/PP2 axis regulates GSDMD-mediated pyroptosis via phosphorylation

Abstract: Gasdermin D (GSDMD), the most important executor of pyroptosis, is activated through caspase cleavage to release the N-terminal fragment (GD-NT), which oligomerizes and…

Date: 2026-08-18

Factors associated with grade ?2 acute radiation dermatitis after adjuvant radiotherapy in breast cancer patients with immediate breast reconstruction: a single-center study using penalized regression

Abstract: Immediate breast reconstruction is increasingly performed in women with breast cancer, yet many such patients also require post-mastectomy radiotherapy (PMRT), during…

Date: 2026-08-18

Efficacy and safety of dalpiciclib combined with endocrine therapy in elderly patients with HR + /HER2 - advanced breast cancer: a real-world study

Abstract: Dalpiciclib shows satisfactory efficacy and safety in patients with hormone receptor-positive (HR + )/human epidermal growth factor receptor 2-negative (HER2 - )…

Date: 2026-08-18

Omission of frozen section in sentinel lymph node biopsy after neoadjuvant chemotherapy in cN0 HER2-positive and TNBC

Abstract: Axillary management in breast cancer has shifted significantly with the increasing use of neoadjuvant chemotherapy (NACT), particularly in biologically aggressive…

Date: 2026-08-18

Association between gut microbiota characteristics and therapeutic efficacy of multimodal combination therapy in hepatocellular carcinoma with portal vein tumor thrombus: a secondary analysis of a prospective phase II trial

Abstract: Hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT) carries a poor prognosis. Although SBRT combined with cadonilimab and lenvatinib has shown…

Date: 2026-08-18

Prevalence and clinicopathological correlates of MSI/dMMR in colorectal cancer: a prospective multicenter registry study from Russia

Abstract: Microsatellite instability/mismatch repair deficiency are well-established predictive biomarkers for immune checkpoint inhibitor therapy and are used to identify…

Date: 2026-08-18

Serplulimab combined with bevacizumab and chemotherapy as first-line treatment for recurrent or metastatic cervical cancer (ASTRUM-CC01): a phase II trial

Abstract: Cervical cancer is one of the leading causes of cancer-related mortality among women worldwide. While immune checkpoint inhibitors combined with bevacizumab and…

Date: 2026-08-18

Evaluation of AI-generated exercise prescriptions for diverse cardiac conditions in rehabilitation: a simulation study using the DeepSeek model

Abstract: Cardiac rehabilitation (CR) significantly improves outcomes for patients with cardiovascular disease, but delivering consistently personalized exercise prescriptions…

Date: 2026-08-18

Development-adjusted inequities and temporal trends in rheumatic heart disease burden across ASEAN countries, 2000–2023

Abstract: Although health indicators have improved across ASEAN, RHD burden remains uneven and its decline relative to socioeconomic development is unclear. This study aimed to…

Date: 2026-08-18