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Radiotherapy-synergized in situ hydrogel vaccine with engineered Lactococcus lactis FOLactis potentiates anti-tumor immunity in pancreatic cancer

Abstract: Immunotherapy has emerged as a promising strategy for pancreatic cancer. Radiotherapy not only mediates direct tumor cell killing but also provides a source of tumor…

Date: 2026-06-29

Clinical evaluation of large language model recommendations in melanoma: comparison with multidisciplinary tumor board decisions in a real-world cohort

Abstract: Large language models (LLMs) are increasingly being studied as potentially valuable support tools in oncology practice including clinical decision support. Yet, their…

Date: 2026-06-29

Evaluating glycolysis-associated biomarkers for radiotherapy sensitivity in head and neck squamous cancer

Abstract: Head and neck squamous cell carcinoma (HNSC) present a significant treatment challenge due to variability in radiotherapy response, where glycolysis may play a pivotal…

Date: 2026-06-29

Systems approach to integrative oncology in breast cancer care: service design, delivery and patient experiences from a UK center

Abstract: Breast cancer affects 2.3 million women annually worldwide, with survivors experiencing substantial unmet supportive care needs around symptom management, lifestyle…

Date: 2026-06-29

Intraoperative irreversible electroporation for margin accentuation in locally advanced intrahepatic cholangiocarcinoma: a case series

Abstract: The incidence of intrahepatic cholangiocarcinoma (iCCA) is increasing worldwide and remains associated with a poor prognosis. Surgical resection is the only potentially…

Date: 2026-06-29

BIRC3-CASP8 axis orchestrates the PANoptosis spectrum: taming the inflammatory storm to prevent post-ischemic heart failure

Abstract: The progression of heart failure (HF) following myocardial ischemia/reperfusion (I/R) injury is driven by regulated cell death. Unlike the restrained nature of…

Date: 2026-06-29

Several antiplatelet gene SNPs, their haplotypes and G × E interactions on premature coronary artery disease

Abstract: To investigate the impact of single nucleotide polymorphisms (SNPs) and haplotypes of antiplatelet drug metabolism-related genes— CYP2C19 , PTGS1 , ITGB3 , PEAR1 , and…

Date: 2026-06-29

The value of speckle tracking echocardiography in early identification of subclinical cardiac involvement in patients with multiple myeloma: a pilot retrospective study

Abstract: Multiple myeloma (MM) is frequently associated with cardiac involvement, particularly myocardial amyloidosis. Current gold-standard diagnostic modalities include cardiac…

Date: 2026-06-26

miR-1248 enhances bortezomib-induced autophagy by targeting MEF2C/p38-MAPK signaling in multiple myeloma

Abstract: Multiple myeloma (MM) is incurable and many patients respond poorly to bortezomib. New strategies to improve bortezomib sensitivity are needed. We screened…

Date: 2026-06-26

Multicenter study on magnesium isoglycyrrhizinate preventing novel antitumor-induced liver injury in hematological malignancies

Abstract: Antineoplastic agents significantly contribute to drug-induced liver injury (DILI). This study evaluates magnesium isoglycyrrhizinate (MgIG) for preventing DILI in…

Date: 2026-06-26