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Engineering with EP2/EP4 knockout and IL-15 transpresentation renders stem cell-derived NK cells self-persistent and resistant to PGE2 inhibition

Abstract: Adoptive Natural Killer (NK) cell transfer is a promising therapy for the treatment of cancer. We developed a GMP-compliant protocol to generate NK cells from…

Date: 2026-06-26

From islet to blood: macrophage remodeling signatures for diagnosis and risk stratification in type 1 diabetes

Abstract: Type 1 diabetes (T1D) is an autoimmune disease characterized by progressive ?-cell destruction, yet current risk stratification tools, which rely mainly on genetic…

Date: 2026-06-26

Association of antiretroviral therapy regimens with serum cortisol abnormalities in people living with HIV/AIDS: a retrospective study

Abstract: The life expectancy of people living with HIV (PLWH) has significantly increased, largely due to the antiretroviral therapy (ART) used very frequently. To explore the…

Date: 2026-06-26

Psychological distress, but not single-time endocrine stress markers, is associated with unexplained infertility: a prospective case–control study

Abstract: Psychological distress is common among women with unexplained infertility and may interact with neuroendocrine stress pathways. However, the relevance of single-time…

Date: 2026-06-26

Metabolic dysregulation and biological age acceleration in Hashimoto’s thyroiditis: a cross-sectional study based on clinical biomarker aging indices and metabolomics

Abstract: Hashimoto’s thyroiditis (HT) is a common autoimmune thyroid disease characterized by thyroid autoantibody positivity, chronic lymphocytic inflammation, and varying…

Date: 2026-06-26

Joint association of triglyceride–glucose index and Chinese visceral adiposity index with prevalent diabetes: a cross-sectional study

Abstract: Diabetes mellitus is strongly associated with insulin resistance and visceral adiposity. Recent studies have demonstrated that the triglyceride–glucose index (TyG) and…

Date: 2026-06-26

Cross-species transcriptomic evidence for peripheral–central immune crosstalk in atopic dermatitis

Abstract: Atopic dermatitis (AD) is characterized by peripheral inflammation and intense pruritus. While itch-induced brain activation in AD is documented, our previous work…

Date: 2026-06-26

Integration of a tele-dermatology model for Epidermolysis Bullosa improves patient outreach: a before and after observational study

Abstract: A hub-and-spokes model strengthens care for Epidermolysis Bullosa by combining specialized expertise with community clinics. Genetic and genomic diagnostics power…

Date: 2026-06-26

High-frequency ultrasound features of cutaneous hidrocystoma: a case series with imaging-pathology correlation

Abstract: Cutaneous hidrocystoma is an uncommon benign cystic lesion of sweat gland origin that frequently presents diagnostic challenges. While clinical examination remains the…

Date: 2026-06-26

Association between the dietary inflammatory index and pregnancy outcomes in women with gestational diabetes mellitus: a prospective cohort study

Abstract: The study aimed to examine the association between late-pregnancy Dietary Inflammatory Index (DII) and pregnancy outcomes among women with gestational diabetes mellitus…

Date: 2026-06-26