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Oncolytic virotherapy counteracts the selection of IFN-unresponsive cancer cells post-immunotherapy but is limited by the emergence of dedifferentiated cancer cells

Abstract: Genetic mutations disrupting interferon (IFN) signaling have been described as an evolutionary route for tumor cells to evade immune checkpoint inhibitor (ICI) therapy.…

Date: 2026-06-22

Clinical characteristics, predictive factors, and therapeutic outcomes of mycoplasma pneumoniae pneumonia with pleural effusion in children: a retrospective cohort study

Abstract: To analyze the clinical characteristics, predictive factors and curative effects of mycoplasma pneumoniae (MP) infection combined with pleural effusion in children. The…

Date: 2026-06-22

Mindsets impact training adaptation and high-pressure performance: beliefs and perceptions of professionals working in elite sport and mission critical teams

Abstract: A critical objective in professional sports and mission critical teams such as specialist police units, military special forces and emergency medicine responders is…

Date: 2026-06-22

Association of metabolic dysfunction-associated steatotic liver disease trajectories with incident liver cancer: a UK Biobank cohort study

Abstract: Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly recognized as a contributor to hepatocellular carcinoma. Whether repeated assessment of…

Date: 2026-06-22

Associations with the quality of life of adult family members or partners (informal carers) of people with leukaemia: results from a cross-sectional online global survey

Abstract: Receiving a leukaemia diagnosis and undergoing treatment impact patients and their informal carers. Our objective was to explore and quantify the impact on the quality…

Date: 2026-06-22

Trajectories of perceived household chaos and youth health outcomes across the COVID-19: insights from individual, dyadic, and triadic family analyses

Abstract: The COVID-19 pandemic profoundly disrupted youth development; however, limited studies have explored the diverse patterns of household environments and their…

Date: 2026-06-22

Environmental and family correlates of daily TV-watching time in children with autism spectrum disorder and typically developing children

Abstract: This study investigated environmental and family factors associated with daily television (TV) watching time among children with autism spectrum disorder (ASD) and…

Date: 2026-06-22

Factors influencing parents’ healthcare-seeking behaviour for their ill children: a cross-sectional study based on China family panel studies

Abstract: Parents’ healthcare-seeking behaviour during their children’s illnesses plays a vital role in ensuring their healthy development. This study conducted a systematic…

Date: 2026-06-22

Risk factors for mis-triage between medical and surgical causes in emergency patients with non-traumatic abdominal pain: a retrospective study

Abstract: To analyze the current status of mis-triage between medical and surgical causes in emergency patients with non-traumatic abdominal pain, explore its influencing factors,…

Date: 2026-06-22

Parental age and age gap in relation to neonatal health: a cohort study in eastern China

Abstract: To investigate the association between parental age, age gap, and neonatal health outcomes, and to provide epidemiological evidence for preconception counseling and…

Date: 2026-06-22