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Mortality trends and disparities in older U.S. adults with atrial fibrillation and COPD: a 1999–2020 CDC WONDER analysis with forecast to 2030

Abstract: Atrial fibrillation (AF) is prevalent in elderly individuals with comorbidities, particularly those with chronic obstructive pulmonary disease (COPD), where their…

Date: 2026-06-23

Pulse pressure and cardiometabolic disease progression: associations with incident multimorbidity and mortality in UK biobank

Abstract: Although pulse pressure (PP) predicts individual cardiometabolic diseases (CMDs), its role in the progression of cardiometabolic multimorbidity (CMM) remains uncertain.…

Date: 2026-06-23

Intradialytic blood pressure instability and associated factors among hemodialysis patients in Somalia: a retrospective study

Abstract: Intradialytic blood pressure (BP) instability—manifesting as intradialytic hypotension (IDH) or hypertension (IDHT)—is increasingly recognized as a contributor to…

Date: 2026-06-23

Ticagrelor plasma concentration, metabolite ratio, and LDH level as independent risk factors for ticagrelor-induced dyspnea in ACS patients

Abstract: Ticagrelor-induced dyspnea is a significant clinical concern and is associated with adverse outcomes. However, the specific risk factors leading to ticagrelor-induced…

Date: 2026-06-23

Gut microbiota and metabolomic characteristics associated with metabolic syndrome in post-cholecystectomy patients: a retrospective cross-sectional study

Abstract: Cholecystectomy (CCE) is widely performed for gallbladder disease, and postoperative bile acid metabolism and gut microbiota homeostasis have attracted increasing…

Date: 2026-06-22

FT3 combined with the TyG index for risk stratification of mild cognitive impairment in euthyroid patients with type 2 diabetes

Abstract: Cognitive impairment is increasingly recognized as an important central nervous system complication of type 2 diabetes mellitus (T2DM). Thyroid hormones (THs) and…

Date: 2026-06-22

Dynamic evolution of readmission risk factors across short-, medium-, and long-term horizons in type 2 diabetes: a machine learning-based predictive modeling study with SHAP interpretability

Abstract: T2DM readmission risk factors may evolve across time windows, but this dynamic remains poorly understood. This retrospective cohort study developed nine machine learning…

Date: 2026-06-22

The linear association between vitamin B12 and diabetic retinopathy in type 2 diabetic patients: a cross-sectional study

Abstract: To examine the association between serum vitamin B12 levels and the prevalence of diabetic retinopathy (DR) among adults with type 2 diabetes mellitus (T2DM). This study…

Date: 2026-06-22

Glycogen metabolic dysfunction in T2DM with MASLD: linking ?-hydroxybutyrate to GYS2 downregulation

Abstract: This study aimed to investigate the molecular characteristics of T2DM with MASLD in a C57 mouse model, using multi-omics techniques to identify key nutritional…

Date: 2026-06-22

Glycemic variability and muscle loss in elderly type 2 diabetes: insights from continuous glucose monitoring and chest CT in 303 patients

Abstract: Sarcopenia is common among older adults with type 2 diabetes mellitus (T2DM). Although chronic hyperglycemia is known to contribute to muscle loss, it remains unclear…

Date: 2026-06-22