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Integrated multi-omics analysis reveals distinct microbiota-metabolite signatures and a novel HCN2-2-hydroxybutyric acid interaction in inflammatory bowel disease

Abstract: Gut microbiota-derived short-chain fatty acids (SCFAs) exert critical regulatory functions in inflammatory bowel disease (IBD). However, integrated profiling of fecal…

Date: 2026-06-23

Endovascular thrombectomy in selected patients with active cancer and thrombocytopenia: outcomes under an institutional platelet transfusion practice

Abstract: Thrombocytopenia is common in patients with active cancer and large vessel occlusion (LVO), raising safety concerns regarding endovascular thrombectomy (EVT). Therefore,…

Date: 2026-06-23

Combined biofeedback and vestibular rehabilitation therapy for vestibular migraine: clinical efficacy and neurobiochemical correlates

Abstract: Vestibular migraine (VM) is a prevalent cause of recurrent vertigo with limited standardized treatment options. While vestibular rehabilitation and biofeedback therapy…

Date: 2026-06-23

The application effect of mini midline catheters in intravenous therapy for neurology patients: real-world evidence from eastern China

Abstract: To investigate the application effect of ultrasound-guided combined with Accelerated Seldinger Technique (AST) for mini midline catheter placement in patients in the…

Date: 2026-06-23

Evaluation of the CIB1R peptide derived from the cytoplasmic domain of neprilysin on cell migration in an in vitro model of lung cancer

Abstract: Lung cancer is characterized by high metastatic potential and poor clinical outcomes, underscoring the need for novel approaches to investigate mechanisms regulating…

Date: 2026-06-23

Early divergence of treatment response trajectories to adalimumab or its biosimilar in active ankylosing spondylitis: consensus clustering analysis of a randomized controlled trial

Abstract: Patients with active ankylosing spondylitis (AS) exhibit substantial heterogeneity in their clinical responses to tumor necrosis factor alpha inhibitors (TNFi).…

Date: 2026-06-23

Comparison of four culture protocols for differentiating bovine peripheral blood mononuclear cells into macrophages

Abstract: Macrophages are essential innate immune cells involved in host defense, tissue homeostasis, and inflammation regulation. In vitro differentiation protocols for…

Date: 2026-06-23

Data-driven trial design: use of target trial emulation to evaluate eligibility criteria in asthma and COPD

Abstract: Clinical trial eligibility criteria are crucial to ensuring valid estimation of therapeutic treatment effects and robust measurement of safety. However, highly…

Date: 2026-06-23

Post-treatment renal function deterioration following radiation therapy: implications for SABR in primary renal cell cancer

Abstract: Definitive renal stereotactic ablative radiotherapy (SABR) is gaining momentum, with promising data showing excellent local control and short-term renal function…

Date: 2026-06-23

Distribution analysis of gynecological carcinomas with concurrent second primary carcinomas

Abstract: This study investigates the distribution characteristics, occurrence time and clinicopathological correlations of second primary carcinoma (SPC) in patients with…

Date: 2026-06-23