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Development and validation of an interpretable machine learning model for predicting 5-year recurrence in breast cancer

Abstract: Accurate prediction of breast cancer recurrence is vital for optimizing adjuvant therapy intensity. However, the traditional TNM staging system often lacks precision in…

Date: 2026-06-10

Integrated single-cell and spatial transcriptomics reveal immune landscape and NKT–Th1 signatures in colorectal cancer

Abstract: Colorectal cancer (CRC) is a prevalent malignancy with high morbidity and mortality. Immunotherapy benefits only a subset of patients, highlighting the need to explore…

Date: 2026-06-10

A stacked cavity-backed metamaterial antenna for confined hyperthermia of subcutaneous fat in ISM band

Abstract: Hyperthermia has emerged as a versatile modality in oncology, rehabilitation, and aesthetic medicine, yet conventional RF devices often suffer from insufficient…

Date: 2026-06-10

Association between the triglyceride–glucose index and subclinical atherosclerosis in asymptomatic adults: a large cross-sectional study of a health check-up population

Abstract: This study aimed to investigate the association between the triglyceride–glucose (TyG) index and subclinical atherosclerosis (SA), hypothesizing that higher TyG levels…

Date: 2026-06-10

Cross-platform evaluation of LLM-generated educational texts on cardiac myxoma: quality, readability, and actionability using network analysis and latent profile analysis

Abstract: Patients with cardiac myxoma require long-term follow-up, and the quality of patient education as well as the ability to recognize early symptoms may influence…

Date: 2026-06-10

Rare pathogenic mutation of KCNH2 p.D501N associated with early-onset malignant long QT syndrome

Abstract: Long QT syndrome (LQTS) is a life-threatening inherited channelopathy that is prone to triggering torsades de pointes (TdP), ventricular tachycardia (VT), ventricular…

Date: 2026-06-10

Vitamin D status and Its association with haematological inflammatory indices and cardiometabolic risk profiles: a retrospective cross-sectional study

Abstract: Cardiovascular disease remains the leading cause of global mortality, with dyslipidaemia and impaired glycaemic control representing central modifiable risk factors.…

Date: 2026-06-10

Impact of clinical pharmacist-led medication management and education on tacrolimus therapeutic control

Abstract: The management of Tacrolimus in pediatric bone marrow transplantation (BMT) presents significant challenges owing to its narrow therapeutic index and considerable…

Date: 2026-06-09

Repeated-dose toxicity and immunogenicity evaluation of norovirus P particle-based rotavirus vaccine in juvenile cynomolgus monkeys

Abstract: Rotavirus remains a major cause of mortality among young children worldwide, underscoring the urgent need for new vaccines. The present study evaluated the repeated-dose…

Date: 2026-06-09

The correlation between serum calcium and asprosin in elderly patients with type 2 diabetes mellitus in community

Abstract: This study aims to investigate the association between serum calcium and asprosin levels in community-dwelling elderly patients with type 2 diabetes mellitus (T2D). It…

Date: 2026-06-09