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Noncanonical NF-?B pathway driven inflammation across multiple cellular compartments identifies NIK as a therapeutic target for inflammatory bowel disease

Abstract: The noncanonical NF-?B pathway, driven by NF-?B-inducing kinase (NIK), plays a central role in inflammatory bowel disease (IBD) pathogenesis by regulating immune…

Date: 2026-06-09

Implications of systolic pulmonary artery pressure trajectories in systemic lupus erythematosus-associated pulmonary hypertension: a CSTAR-PAH cohort study

Abstract: To identify the evolution trajectory of systolic pulmonary artery pressure (sPAP) in patients with systemic lupus erythematosus-related pulmonary arterial hypertension…

Date: 2026-06-09

Angiosarcoma in a soft tissue sarcoma cohort: real-world patterns and outcomes

Abstract: Angiosarcoma is a rare, aggressive vascular sarcoma with heterogeneous clinical presentation and limited real-world outcome data. We retrospectively reviewed adult soft…

Date: 2026-06-09

RSPO2-induced ferroptosis via PTBP1-mediated FSP1 mRNA decay suppresses breast cancer progression

Abstract: Breast cancer is the most common malignant tumor worldwide, and its high heterogeneity limits the efficacy of current clinical therapies. R-spondin 2 (RSPO2) expression…

Date: 2026-06-09

Subcutaneous patient-controlled analgesia with hydromorphone for the treatment of refractory cancer pain in older hospitalized patients: a retrospective real-world study

Abstract: Refractory cancer pain remains difficult to control in older adults, particularly when oral opioid regimens are limited by dysphagia, nausea, bowel dysfunction, or…

Date: 2026-06-09

SIMVASTATIN as a potential protective strategy against doxorubicin-induced cardiotoxicity

Abstract: Doxorubicin-induced cardiotoxicity (DIC) represents a major limitation in oncology, leading to ventricular dysfunction and long-term morbidity. Lipophilic statins, such…

Date: 2026-06-09

Baseline vs. on-treatment heart failure with preserved ejection fraction (HFpEF) in a real world cardio-oncology clinic: observational analysis of cancer therapy-related cardiovascular toxicity incidence and cancer treatment implications

Abstract: Heart failure with preserved ejection fraction (HFpEF) prevalence increases, but in cancer patients undergoing potentially cardiotoxic treatments, HFpEF is not included…

Date: 2026-06-09

Efficacy and safety of transcatheter left atrial appendage closure guided by transoesophageal echocardiography using standard and micro TEE probes: a single-center retrospective study

Abstract: Transcatheter left atrial appendage closure (T-LAAC) represents an effective alternative to long-term anticoagulation in patients with atrial fibrillation (AF) and…

Date: 2026-06-09

Elevated homocysteine levels are associated with increased diabetes risk in patients with hypertension: a multicenter longitudinal study

Abstract: Previous studies have consistently confirmed an association between homocysteine (Hcy) and hypertension. However, whether homocysteine is also associated with diabetes…

Date: 2026-06-09

High prevalence of thyroid nodules and their association with cardiometabolic risk in Mongolia

Abstract: Mongolia faces rising rates of obesity, diabetes, and cardiovascular disease, yet little is known about their relationship with thyroid nodules. This study aimed to…

Date: 2026-06-08