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Association between tumor genomic mutations and the risk of PD-1 inhibitor-induced hypophysitis: a retrospective cohort study

Abstract: Immune checkpoint inhibitors (ICIs) can cause immune-related adverse events (irAEs), with hypophysitis being a serious endocrine toxicity that often requires hormone…

Date: 2026-06-08

Interaction between fatty pancreas disease and genetically predicted glucose-dependent insulinotropic polypeptide on incident type 2 diabetes: evidence from the UK Biobank

Abstract: Glucose-dependent insulinotropic polypeptide (GIP) plays a crucial role in lipid metabolism. The effect of GIP on pancreatic lipid and whether it modulates risk of type…

Date: 2026-06-08

LncRNA GAS8-AS1 is downregulated, correlates with early-stage disease and lymph node metastasis, and its knockdown promotes proliferation, migration, and invasion in differentiated thyroid cancer

Abstract: LncRNAs emerge as critical regulators of gene expression and epigenetic modulation in human cancer. However, the biological and clinical significance of the lncRNA…

Date: 2026-06-08

Heat-processed rodent chow alters nutritive content and improves metabolic outcomes in insulin-resistant female mice

Abstract: Animal research diets are often autoclaved for sterilization. Autoclaved chow can also serve as a model for investigating the health effects of heat-processed foods.…

Date: 2026-06-08

Diabetes-related stigma among individuals with type 1 diabetes in Jazan, Saudi Arabia: sociodemographic and clinical correlates

Abstract: Diabetes-related stigma can negatively affect self-management, psychological well-being, and health outcomes among people living with diabetes; however, its correlates…

Date: 2026-06-08

Differentiation defects reposition sebaceous glands as inflammatory instigators in the early pathogenesis of hidradenitis suppurativa

Abstract: The role of sebaceous glands (SGs) in the early pathogenesis of hidradenitis suppurativa (HS) remains undefined, with an unclear causal relationship to inflammatory…

Date: 2026-06-08

Development and validation of a skin health knowledge, attitudes, and behaviors questionnaire for the general population: a cross-sectional study

Abstract: Existing skin health assessments predominantly focus on single topics or diseases, making it difficult to cover the complete “Knowledge–Self-efficacy–Attitudes–Behaviors…

Date: 2026-06-08

Prevalence of psychological and metabolic concerns in children with white coat and ambulatory hypertension

Abstract: White Coat Hypertension (WCH), or elevated blood pressure in response to stress, is common in childhood. While studies showed that hypertension (HTN) can be associated…

Date: 2026-06-08

Development and internal validation of a nomogram for early prediction of hospital-acquired ESKAPE colonization or infection in very preterm infants using indicators available within 24 hours

Abstract: ESKAPE pathogens are a major cause of hospital-acquired colonization or infection among very preterm infants in neonatal intensive care units ( N ICUs). Early…

Date: 2026-06-08

A novel nutritional tool to identify infants at risk of stunting

Abstract: This study aimed to develop and validate a novel scoring system and prediction algorithm integrating growth, nutritional, and biochemical indicators for the…

Date: 2026-06-08