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Efficacy and safety of PARP inhibitor maintenance therapy in elderly ovarian cancer patients: a real-world single-center retrospective cohort study

Abstract: PARP(Poly(ADP-ribose) polymerase) inhibitors are established as effective treatment for ovarian cancer; however, there have been no systematic studies of PARP inhibitor…

Date: 2026-06-08

Association between low magnesium status and new-onset dementia in the general population: a propensity score-matched cohort study

Abstract: Low magnesium status has been linked to cerebrovascular conditions that overlap with pathways implicated in dementia, yet prior studies have relied on single magnesium…

Date: 2026-06-08

Motivational neurobehavioral abnormalities under a naturalistic goal-conflict task in patients with premenstrual dysphoric disorder

Abstract: Motivation drives goal-directed behavior, often requiring individuals to approach rewards while facing potential punishment (i.e., goal-conflict). Premenstrual dysphoric…

Date: 2026-06-08

Retrospective evaluation of the prevalence of known and presumed hereditary eye diseases in a population of Labradoodles referred for ophthalmic screening examinations in the Netherlands

Abstract: The popularity of designer crossbreed dogs, including Labradoodles, has increased markedly in recent years. This retrospective study evaluated ophthalmic findings and…

Date: 2026-06-08

Digital eye strain among Indian university students in the post-COVID era: a cross-sectional study

Abstract: Digital Eye Strain (DES), also known as Computer Vision Syndrome (CVS), has become increasingly prevalent with the expansion of digital device use, particularly in…

Date: 2026-06-08

Widefield SS-OCTA-detected retinal vascular changes and their correlation with DME in diabetes

Abstract: This study investigated retinal blood flow alterations in diabetic macular edema (DME) using ultra-widefield optical coherence tomography angiography (OCTA). We enrolled…

Date: 2026-06-08

V-shaped capsular plication for treating cam-type femoroacetabular impingement with hip instability in borderline dysplastic hips: a retrospective cohort study

Abstract: Purpose Patients with cam-type femoroacetabular impingement (FAI) frequently present with concomitant borderline developmental dysplasia of the hip (BDDH), a critical…

Date: 2026-06-08

Laminectomy vs. laminoplasty for treating multi-segment cervical canal stenosis combined with central cord syndrome in the absence of fracture or dislocation: a retrospective study

Abstract: Laminectomy fusion fixation (LF) and single open-door laminoplasty (LP) are common posterior surgeries for central cord syndrome without fracture/dislocation (CCSWOFD),…

Date: 2026-06-08

Development and internal validation of a prediction model for hypoxic hepatitis after coronary artery bypass grafting with cardiopulmonary bypass

Abstract: Hypoxic hepatitis (HH) after on-pump coronary artery bypass grafting (CABG) is associated with poor outcomes, but dedicated prediction tools are lacking. We developed…

Date: 2026-06-08

TPPU protects against seizures and seizure-associated comorbidities by inhibiting the Akt/mTOR signaling pathway in KA-induced convulsant mice

Abstract: Shared pathophysiological mechanisms exist between epilepsy and its associated comorbidities, with neuroinflammation playing a key role.…

Date: 2026-06-08