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A novel homozygous ARFGEF2 splice-site variant causing periventricular nodular heterotopia with microcephaly

Abstract: The ARFGEF2 gene encodes the brefeldin A (BFA)-inhibited GEF2 protein (BIG2), which is distributed in the trans-Golgi network and plays a crucial role in neuronal…

Date: 2026-05-22

Real-world study of efgartigimod in AChR antibody-positive generalized myasthenia gravis: thymus status, multi-domain symptom improvement and steroid-sparing effect

Abstract: Efgartigimod has been approved for the treatment of gMG. However, real-world evidence regarding its efficacy across various functional domains in patients with differing…

Date: 2026-05-22

?-Galactosylceramide-expanded virtual memory CD8 + T cells confer protection against a broad range of pathogens

Abstract: ?-Galactosylceramide (?-GalCer) treatment of animals is a well-established model to investigate the beneficial roles of invariant natural killer T (iNKT) cells in…

Date: 2026-05-22

Acquired angioedema due to C1 inhibitor deficiency: real-world clinical characteristics and treatment outcomes

Abstract: Acquired angioedema due to C1 inhibitor deficiency (AAE-C1INH) is a rare bradykinin-mediated condition that may mimic hereditary angioedema (HAE). Management is largely…

Date: 2026-05-22

Spatially microdissected profiling of tonsillar germinal centers reveals a KLRG1-enriched immune signature in IgA nephropathy

Abstract: Geographic variability in the clinical efficacy of tonsillectomy for immunoglobulin A nephropathy (IgAN) suggests population-level differences in mucosal immune…

Date: 2026-05-22

Application of failure mode and effects analysis combined with bundled management measures in reducing ICU-acquired infections

Abstract: To systematically evaluate the application value and implementation effectiveness of a Failure Mode and Effects Analysis (FMEA)-based bundled management strategy in the…

Date: 2026-05-22

In-house 3D printed porous implants: does strontium-coating enhance osseointegration? An in-vivo study in large animals

Abstract: Early osseointegration is essential for the long-term success of uncemented custom-made prostheses, particularly in oncologic bone reconstruction where bone stock is…

Date: 2026-05-22

Technical evaluation of non-coplanar lattice radiotherapy: achieving directional VPDR uniformity with a 5-mm leaf width multi-leaf collimator

Abstract: Spatially fractionated radiation therapy (SFRT) creates alternating high-dose peaks and low-dose valleys for treating bulky tumors, with optimal biological effects…

Date: 2026-05-22

Real-world treatment patterns and outcomes for patients with extensive-stage small-cell lung cancer treated in US community oncology practices

Abstract: Extensive-stage small-cell lung cancer (ES-SCLC) is an aggressive malignancy with a poor prognosis. Advances have been made in the treatment landscape in the past…

Date: 2026-05-22

Acute and late toxicity in prostate cancer patients treated with moderately vs ultra-hypofractionated radiotherapy

Abstract: Prostate cancer is the most frequently diagnosed male malignancy in Colombia. While modern radiotherapy techniques allow for hypofractionated schedules due to the low…

Date: 2026-05-22