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Discovery and validation of a robust 11-gene prognostic signature via integrative multi-omics profiling in VD-CAG-treated non-M3 AML

Abstract: While the venetoclax-based VD-CAG regimen has shown promising efficacy in acute myeloid leukemia (AML), its underlying molecular response mechanisms remain poorly…

Date: 2026-05-19

Fathers’ perspectives on the breastfeeding experience: a qualitative study

Abstract: Breastfeeding offers numerous short-, medium-, and long-term benefits for the physical and mental health of both mother and child and strengthens the bond between them.…

Date: 2026-05-19

Single-cell transcriptome delineating asymmetric dynamics of CD4 + T and CD8 + T cell lineage commitment in human prenatal thymus

Abstract: The thymus provides a specialized microenvironment for T cell development and selection, yet the cellular heterogeneity and molecular dynamics that govern human prenatal…

Date: 2026-05-19

Identification and experimental validation of mitochondria pathway related genes in acute myeloid leukemia

Abstract: Acute myeloid leukemia (AML) is a hematologic malignancy characterized by heterogeneity, poor prognosis, and limited biomarkers for risk prediction. Mitochondria pathway…

Date: 2026-05-19

Paired ctDNA analysis reveals diverse resistance mechanisms to mobocertinib in EGFR exon 20 insertion NSCLC

Abstract: Epidermal growth factor receptor (EGFR) exon 20 insertion mutations in non-small cell lung cancer (NSCLC) represent a distinct molecular subset with limited response to…

Date: 2026-05-19

Prognostic heterogeneity in ASXL1-mutated AML and refinement by an immunophenotype-based score

Abstract: ASXL1 is a frequently mutated gene in acute myeloid leukemia (AML) and is clinically recognized as an adverse prognostic marker, yet its clinical impact remains markedly…

Date: 2026-05-19

Familial investigation of two cases of pseudohypoparathyroidism

Abstract: To report the clinical and genetic characteristics of patients diagnosed with pseudohypoparathyroidism (PHP) or inactivating parathyroid hormone (PTH)/PTHrP signaling…

Date: 2026-05-19

A multi-stage validation of the C-reactive protein–triglyceride–glucose index for predicting mild cognitive impairment: evidence from clinical and nationwide prospective cohorts

Abstract: Mild cognitive impairment (MCI) is a common but under-recognized complication of type 2 diabetes mellitus (T2DM), and practical predictors are limited. The C-reactive…

Date: 2026-05-19

Pubertal dysfunctions in intracranial germ cell tumors

Abstract: Pediatric intracranial germ cell tumors (IC-GCTs) are frequently associated with pubertal dysfunctions, either at diagnosis or during follow-up. This study aims to…

Date: 2026-05-19

Adjunctive topical mesenchymal stem cell-derived secretome-enriched biological dressings in pediatric complex wounds: a retrospective case series

Abstract: Mesenchymal stem cell (MSC)-derived secretome, including extracellular vesicles (EVs), has emerged as a potential cell-free regenerative approach due to its…

Date: 2026-05-19