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Effects of SOX10 on the proliferative, invasive, migratory, and epithelial–mesenchymal transition abilities of triple-negative breast cancer cells

Abstract: Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer with limited targeted therapeutic options. Sry-related HMG-box gene 10 (SOX10) has…

Date: 2026-05-18

Impact of bone cement leakage on early postoperative pain in percutaneous vertebroplasty for osteoporotic vertebral compression fractures

Abstract: This study aimed to explore the impact of bone cement leakage and its distribution on early postoperative pain following percutaneous vertebroplasty (PVP) for…

Date: 2026-05-18

Chronic anterior talofibular ligament rupture is associated with bilateral knee alterations and reduced ankle plantar flexor moment during gait

Abstract: With the increasing clinical burden of ankle injuries, particularly anterior talofibular ligament (ATFL) rupture, understanding their biomechanical impact on gait has…

Date: 2026-05-18

Multimodal integration of neuroimaging, transcriptomics and single-cell analysis reveals molecular correlates linking osteoporosis to brain abnormalities

Abstract: Osteoporosis (OP) and cognitive decline are highly prevalent comorbidities; however, the molecular mechanisms linking them remain unclear. We adopted a multimodal…

Date: 2026-05-18

Long-term effectiveness and safety of vedolizumab in ulcerative colitis: a real-world retrospective cohort study over 2?years

Abstract: Vedolizumab (VDZ), a gut-selective anti-integrin therapy, has demonstrated efficacy in ulcerative colitis (UC) clinical trials, but real-world long-term data from Asia,…

Date: 2026-05-18

Pan-immune inflammation value and neutrophil-to-albumin ratio predict hemorrhagic transformation after intravenous thrombolysis in acute ischemic stroke: a dual-center cohort study

Abstract: Hemorrhagic transformation (HT) remains a critical complication of intravenous thrombolysis (IVT) in acute ischemic stroke (AIS), yet reliable pre-thrombolysis…

Date: 2026-05-18

Association between intracranial arterial stenosis severity and recurrent stroke risk in elderly ischemic stroke patients

Abstract: Intracranial arterial stenosis (ICAS) is a major cause of ischemic stroke in older adults and is associated with substantial risk of recurrent cerebrovascular events.…

Date: 2026-05-18

Clinical profile of headache attributed to anxiety and depressive disorders: an observational study

Abstract: Headache attributed to anxiety or depressive disorders was added to the appendix of the International Classification of Headache Disorders, 3rd edition (ICHD-3) in 2018.…

Date: 2026-05-18

IgA anti-CD74 autoantibodies are associated with treatment escalation in peripheral psoriatic arthritis

Abstract: Psoriatic arthritis (PsA) often requires escalation from conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) to biologic therapy (bDMARDs), yet…

Date: 2026-05-18

Preparedness for generative AI adoption among Chinese cancer survivors: a multi-center cross-sectional survey study

Abstract: Generative artificial intelligence (GenAI) is rapidly entering consumer health information environments, yet patient readiness for safe adoption in cancer survivorship…

Date: 2026-05-18