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Machine learning-based prediction of ischemic cardio-cerebrovascular events after endovascular or microsurgical treatment of unruptured intracranial aneurysms and risk stratification by the early post-treatment triglyceride-glucose index

Abstract: Ischemic cardio-cerebrovascular events (ICCEs), including acute coronary syndrome and ischemic cerebral infarction, remain clinically important complications after…

Date: 2026-05-13

Three-year real-world effectiveness, treatment persistence, and planned discontinuation of anti-calcitonin gene-related peptide monoclonal antibodies for migraine prevention: a single-center cohort from Japan

Abstract: Long-term real-world evidence beyond 24?months for anti-calcitonin gene-related peptide (CGRP) monoclonal antibodies is scarce, particularly regarding treatment…

Date: 2026-05-13

Proportions, trends, and outcomes of posterior circulation ischemic stroke in the United States

Abstract: Posterior circulation ischemic stroke has been previously studied in single-center and multicenter registries. The contemporary proportions, trends, and outcomes of…

Date: 2026-05-13

The significance of CEACAM60, a carcinoembryonic antigen (CEA) homolog, as a tumor antigen in the porcine cancer model

Abstract: Translational medicine remains one of the central challenges in modern biomedical research. A major bottleneck in this field is the limited availability of suitable…

Date: 2026-05-13

Baseline serum cortisol as a prognostic biomarker for immune checkpoint inhibitor therapy in advanced gastric cancer

Abstract: Immune checkpoint inhibitors (ICIs) have transformed the treatment of advanced gastric cancer (AGC), but only a subset of patients benefit. Validated prognostic…

Date: 2026-05-13

Interrelations of disease activity, health-related quality of life, and mental health in axial spondyloarthritis: the Rheuma-VOR cohort

Abstract: Axial spondyloarthritis (axSpA) is a chronic inflammatory rheumatic disease characterized by pain and stiffness of the axial skeleton, peripheral manifestations like…

Date: 2026-05-13

Rehmannioside A alleviates neuroinflammation and cognitive impairments after traumatic brain injury by suppressing microglial activation via the MAPK/NF-?B pathway

Abstract: Traumatic brain injury (TBI) triggers a robust neuroinflammatory response characterized by microglial activation, which propagates secondary neuronal damage and…

Date: 2026-05-13

New insights gained from a decade long multi-center retrospective study on the management strategy for heterotopic pregnancy: expectant management is worth considering in patients without vaginal bleeding

Abstract: Heterotopic pregnancy (HP) is a rare but clinically challenging condition because treatment of the ectopic component must be balanced against preservation of the…

Date: 2026-05-13

Assessment of treatment outcomes in patients with breast cancer who underwent mastectomy and breast reconstruction with sparing of the areola-nipple complex – single-center analysis

Abstract: Despite significant improvements in early detection of breast cancer, some patients still require mastectomy. One clinical problem currently being analyzed is the…

Date: 2026-05-13

Prediction of clinical outcomes of advanced cutaneous squamous cell carcinoma to PD-1 inhibition directly from histopathology slides using inferred transcriptomics

Abstract: Metastatic or locally advanced cutaneous squamous cell carcinoma (cSCC) that is not amenable to local therapy is treated with programmed death-1 (PD-1) inhibitors.…

Date: 2026-05-13