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Real-world efficacy and safety of Tenecteplase versus Alteplase in acute ischemic stroke: a propensity score-matched analysis

Abstract: Real-world evidence comparing Tenecteplase and Alteplase for acute ischemic stroke (AIS) remains limited. This study aimed to evaluate the comparative efficacy and…

Date: 2026-05-12

Efficacy and safety of efgartigimod as an add-on therapy in patients with NMOSD and MOGAD at the acute attack phase

Abstract: Neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein-associated disease (MOGAD) are autoimmune antibody-mediated diseases.…

Date: 2026-05-12

Stress accelerates hepatocellular carcinoma progression via a gut microbial-metabolite axis

Abstract: Hepatocellular carcinoma ranks among the most prevalent malignancies worldwide. While stress can modulate tumor initiation, progression, metastasis, and therapeutic…

Date: 2026-05-12

Integrase inhibitor–based antiretroviral therapy drives gut microbiota remodeling and immune recovery in HIV infection

Abstract: The gastrointestinal tract serves as a major viral reservoir in HIV infection, and persistent gut dysbiosis contributes to systemic inflammation and immune dysfunction…

Date: 2026-05-12

Downregulation of PRPS2 inhibits tumor growth of non-small cell lung cancer by suppressing PI3K/AKT signaling

Abstract: This study aims to investigate the role of phosphoribosyl pyrophosphate synthetases 2 (PRPS2) in non-small cell lung cancer (NSCLC) and its underlying molecular…

Date: 2026-05-12

Multi-omics investigation of perineural invasion in head and neck squamous cell carcinoma: neuroimmune mechanisms and clinical implications

Abstract: Perineural invasion (PNI) is an aggressive feature in head and neck squamous cell carcinoma (HNSCC), but its molecular basis and neuroimmune implications, including…

Date: 2026-05-12

Learning curve of distal transradial access for coronary intervention: a single-center retrospective study

Abstract: The vascular access site for coronary intervention has evolved from the femoral artery to the conventional radial artery; more recently, the distal transradial access…

Date: 2026-05-12

Long-term clinical efficacy of Marshall vein ethanol infusion combined with catheter ablation for persistent AF

Abstract: Recurrent atrial arrhythmia after radiofrequency catheter ablation (RFCA) for persistent atrial fibrillation (AF) necessitates better strategies. Ethanol infusion of the…

Date: 2026-05-12

GLP-1 receptor agonists alleviate inflammatory responses and endothelial dysfunction in atherosclerosis by activating the Sema3A/NRP1 pathway

Abstract: This study aimed to investigate the mechanism by which GLP-1 RAs activate the Sema3A/NRP1 signaling pathway to alleviate inflammation and endothelial dysfunction in…

Date: 2026-05-12

Time to chemotherapy and oncofertility counseling in pediatric hematology/oncology patients: a single-center retrospective review

Abstract: The American Society of Reproductive Medicine and American Society of Clinical Oncology emphasize the importance of oncofertility counseling in pediatric cancer…

Date: 2026-05-11