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Expression of ATRX, DAXX, PDX1, ARX, and somatostatin receptors in pancreatic neuroendocrine tumors: a clinicopathological study

Abstract: Recent studies have identified ATRX/DAXX and PDX1/ARX as biomarkers defining novel pancreatic neuroendocrine tumor (PanNET) subtypes, while the clinical significance of…

Date: 2026-05-11

Associations of FGF23 and Apelin-13 with osteoporosis and diabetic peripheral neuropathy in postmenopausal women with type 2 diabetes mellitus

Abstract: To investigate the correlations of various clinical indicators, fibroblast growth factor 23 (FGF23), and Apelin-13 with osteoporosis (OP) and diabetic peripheral…

Date: 2026-05-11

Clinical validation of an artificial intelligence model for thyroid fine-needle aspiration biopsy indication: comparison with TI-RADS systems and human specialists in a Chilean public hospital

Abstract: Ultrasound evaluation of thyroid nodules shows significant interobserver variability, contributing to the overutilization of fine-needle aspiration biopsy (FNA).…

Date: 2026-05-11

Association of cholesterol, high-density lipoprotein, and glucose (CHG) index with chronic kidney disease in Chinese community adults: findings from the REACTION study

Abstract: While a limited-scale study in Turkey identified an association between the cholesterol, high-density lipoprotein, and glucose (CHG) index and diabetic nephropathy,…

Date: 2026-05-11

Bone mineral density and bone turnover in adolescent girls with anorexia nervosa: a 3-year retrospective cohort study

Abstract: Adolescent girls with anorexia nervosa (AN) are at high risk of reduced bone mineral density (BMD) due to chronic malnutrition, hypogonadism, and endocrine disturbances.…

Date: 2026-05-11

Dapagliflozin associates with heart rate variability decline in T2DM patients on GLP-1 receptor agonist therapy: a prospective observational study

Abstract: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are associated with increased heart rate (HR) and reduced heart rate variability (HRV) in patients with type 2…

Date: 2026-05-11

Dapagliflozin and linagliptin combination therapy improves time in range and reverses hepatic steatosis in patients with type 2 diabetes and hypertension

Abstract: Type 2 diabetes mellitus (T2DM) with comorbid hypertension increases risks of vascular complications, necessitating optimized therapies. This study evaluated whether…

Date: 2026-05-11

Objective assessment of rosacea erythema severity: a multimodal artificial intelligence framework integrating VISIA® imaging and image-derived tabular features

Abstract: Rosacea is a chronic inflammatory skin disorder characterized by persistent facial erythema. Its clinical assessment relies on the Clinician’s Erythema Assessment (CEA),…

Date: 2026-05-11

High-fat diet-induced obesity impairs endothelium-dependent relaxation in rabbits: association with MLCK upregulation and partial ex vivo improvement by ML-7

Abstract: Obesity is an independent risk factor for cardiovascular diseases and elevated mortality, yet the underlying mechanisms remain incompletely understood. Impaired…

Date: 2026-05-11

Prediction of atelectasis in Mycoplasma pneumoniae pneumonia using a SHapley Additive exPlanations-interpretable machine learning model

Abstract: This study aimed to evaluate the performance of three machine learning models—K-nearest neighbors (KNN), support vector machine (SVM), and neural network (NN)—for…

Date: 2026-05-11