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From in silico to in vitro : discovery and validation of peptide modulators of IL-6/IL-6R signaling in rheumatoid arthritis

Abstract: Rheumatoid arthritis (RA) is a chronic autoimmune disease in which dysregulated interleukin-6 (IL-6) signaling through the IL-6 receptor (IL-6R) plays a central…

Date: 2026-04-29

Metabolic syndrome and risk of incident chronic pancreatitis: a prospective cohort study

Abstract: The association between metabolic syndrome (MetS) and chronic pancreatitis (CP) remains unclear. This study aimed to examine whether MetS is independently associated…

Date: 2026-04-29

Role of enteral nutrition in the clinical care, management, and quality of life of patients with inflammatory bowel disease

Abstract: Enteral nutrition (EN) is essential for Inflammatory Bowel Disease treatment. This applies mainly to Crohn’s disease (CD) and ulcerative colitis (UC) patients. The study…

Date: 2026-04-29

Research trends on autoimmune liver diseases and gut microbiota (1989–2025): a bibliometric and visualization analysis based on the web of science core collection database

Abstract: Autoimmune liver diseases (AILD) encompass autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC), and IgG4-related…

Date: 2026-04-29

Transcultural adaptation and validation of the Chinese version of the Visceral Sensitivity Index for patients with disorders of gut-brain interaction

Abstract: Gastrointestinal-specific anxiety (GSA) is a critical psychosomatic factor influencing symptom perception and quality of life in disorders of gut-brain interaction…

Date: 2026-04-29

Alterations of cognitive function and hippocampal metabolism in asymptomatic neurosyphilis patients: based on 1 H-magnetic resonance spectroscopy

Abstract: Neurosyphilis has been found to be associated with cognitive decline. However, as a common type of neurosyphilis, the change of cognitive function in asymptomatic…

Date: 2026-04-29

Long-term mortality and time to minimally invasive puncture and drainage in spontaneous intracerebral hemorrhage

Abstract: Minimally invasive puncture and drainage (MIPD) is a safe and effective treatment for spontaneous intracerebral hemorrhage (sICH). However, the impact of time to…

Date: 2026-04-29

Factors associated with laboratory-confirmed measles cases during the 2023 and 2024 outbreaks in Tanzania—a mixed-methods study

Abstract: Despite the introduction of the two-dose measles-containing vaccine (MCV2) in 2014, measles remains a persistent public health problem in Tanzania, characterized by…

Date: 2026-04-29

A systematic seminar-based model improves learning and research competence in an immunology graduate course: a quasi-experimental mixed-methods study

Abstract: Medical immunology, a bridging discipline between basic and clinical medicine, is characterized by rapid knowledge updates, multidisciplinary integration, and fast…

Date: 2026-04-29

Ultrasound-based radiomics and habitat analysis for noninvasive assessment of Ki-67 overexpression in breast cancer

Abstract: Accurate preoperative assessment of Ki-67 proliferation index remains a clinical challenge in breast cancer management. Conventional ultrasound radiomics often fails to…

Date: 2026-04-29