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Limonin alleviates pyroptosis and inflammatory responses in cardiomyocytes of myocardial ischemia-reperfusion mice by inhibiting the caspase-3/GSDME pathway

Abstract: Myocardial ischemia-reperfusion (I/R) is characterized by myocardial cell death and exacerbated inflammatory responses that seriously affect cardiac function and patient…

Date: 2026-04-29

Pan-cancer analysis reveals the prognostic and therapeutic relevance of MEX3A with a focus on chromophobe renal cell carcinoma

Abstract: MEX3A is an RNA-binding protein implicated in post-transcriptional regulation; however, its role across cancers, particularly in chromophobe renal cell carcinoma…

Date: 2026-04-29

Differential expression of GLP1R, PCSK9, and SGLT2 in human aortic versus mitral valve tissues: exploratory findings in calcific aortic valve disease

Abstract: Calcific aortic valve disease (CAVD) is a common valvular heart disorder for which effective pharmacological treatments remain lacking. This study aimed to compare the…

Date: 2026-04-29

Palmitic and oleic acids induce macrophage foam cell formation through C/EBP? activation

Abstract: Foam cell formation is a critical early event in atherosclerosis. While oxidized low-density lipoprotein (oxLDL)-driven mechanisms are well studied, the contribution of…

Date: 2026-04-29

Surpassing genetic height potential at final adult height after monthly depot leuprolide therapy in Taiwanese girls with central precocious or early puberty: a ROC-based analysis

Abstract: Gonadotropin-releasing hormone agonists (GnRHa) are widely used to treat central precocious puberty (CPP), yet long-term outcomes based on confirmed final adult height…

Date: 2026-04-28

An extra virgin olive oil diet impairs glycemic control, but mitigates high-fat diet-induced inflammation compared to coconut oil in mice

Abstract: Extra virgin olive oil is widely regarded as a metabolically beneficial dietary component due to its anti-inflammatory and antioxidant properties, but its effects on…

Date: 2026-04-28

Subclinical muscle softening in type 2 diabetes: a shear wave elastography study linking mechanical properties to metabolic profiles

Abstract: Skeletal muscle is a critical target organ in type 2 diabetes mellitus (T2DM). While muscle atrophy is a well-recognized complication, qualitative tissue remodeling…

Date: 2026-04-28

Impact of gastrointestinal multiplex PCR on the diagnosis, clinical correlation, and antimicrobial stewardship in pediatric acute gastroenteritis

Abstract: Acute gastroenteritis (AGE) is a major cause of childhood morbidity and mortality worldwide, yet pathogen identification often remains elusive. Gastrointestinal (GI)…

Date: 2026-04-28

Superiority of long peripheral catheters over short peripheral catheters for completing planned infusion therapy in late preterm and term neonates: a retrospective cohort study with competing-risk analysis

Abstract: Long peripheral catheters (LPCs) are increasingly used as alternatives to short peripheral catheters (SPCs) in neonatal intensive care units, but their effectiveness for…

Date: 2026-04-28

Impact of levonorgestrel-releasing intrauterine device on amenorrhea rates after endometrial resection or ablation in women with abnormal uterine bleeding

Abstract: To evaluate the impact of adjunctive levonorgestrel-releasing intrauterine device (LNG-IUD) placement on amenorrhea rates and hysterectomy risk following endometrial…

Date: 2026-04-28