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Pediatric ectodermal dysplasia with immunodeficiency caused by a hemizygous IKBKG frameshift variant: a case report and literature review

Abstract: This case report looks at a child’s ectodermal dysplasia with immunodeficiency ( EDA-ID ), caused by a mutation in the IKBKG gene, and other relevant cases. A pediatric…

Date: 2026-09-15

Treatment patterns, intensive treatment, and hospitalization-related burden of juvenile generalized myasthenia gravis in Japan: a retrospective cohort study using a hospital-based claims database

Abstract: Juvenile generalized myasthenia gravis (MG) management aims to control symptoms while minimizing corticosteroid-related toxicity. However, large-scale evidence on…

Date: 2026-09-15

Development of an interpretable machine learning model for predicting in-hospital mortality in ICU patients with sepsis: a retrospective cohort study

Abstract: Sepsis ranks among the primary causes of mortality in intensive care units (ICUs), often resulting in multiple organ dysfunction due to dysregulated systemic…

Date: 2026-09-15

Development and validation of a nomogram predicting the risk of necrosis in fingertip replantation: a single-center retrospective study

Abstract: Necrosis remains an important complication after fingertip replantation. We aimed to develop and internally validate a model for estimating necrosis risk using clinical,…

Date: 2026-09-15

From disease to syndrome pattern: a study on the differentiation of traditional Chinese medicine syndrome patterns in asthma using multi-omics characterization

Abstract: Bronchial asthma is a highly heterogeneous chronic inflammatory airway disorder. Syndrome differentiation-guided Traditional Chinese Medicine (TCM) treatment for asthma…

Date: 2026-09-15

Development of multi-algorithm machine learning models integrating novel serum biomarkers for survival prediction in colorectal cancer: a retrospective cohort study

Abstract: Colorectal cancer (CRC) prognosis prediction remains challenging due to tumor heterogeneity, and existing machine learning-based prognostic studies often rely on single…

Date: 2026-09-15

Predictive models for the occurrence of expansive intracranial hematomas and outcomes after surgical evacuation in patients with traumatic brain injury in Uganda: a prospective cohort study

Abstract: Hematoma expansion is a frequent and clinically important complication of traumatic intracranial hemorrhage and is associated with poor functional outcomes. Early…

Date: 2026-09-15

Deep learning-based multiclass classification for the diagnosis of hand arthritis on digital radiography: a multicenter study

Abstract: To develop and independently validate a deep learning framework for multiclass differentiation of osteoarthritis (OA), rheumatoid arthritis (RA), gouty arthritis (GA),…

Date: 2026-09-15

Tumor apparent diffusion coefficient combined with the lipid-to-creatine ratio for preoperative differentiation of primary central nervous system lymphoma from high-grade glioma: a single-center diagnostic model development and internal validation study

Abstract: Primary central nervous system lymphoma (PCNSL) and high-grade glioma (HGG) may share overlapping conventional MRI appearances. We developed and internally validated a…

Date: 2026-09-15

Development and internal validation of a macrophage migration inhibitory factor-based risk assessment model for delayed cerebral ischemia in patients with aneurysmal subarachnoid hemorrhage

Abstract: Delayed cerebral ischemia (DCI) is an important cause of poor outcomes in patients with aneurysmal subarachnoid hemorrhage (aSAH). Macrophage migration inhibitory factor…

Date: 2026-09-15