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Mutant HVEM in lymphoma disrupts BTLA and CD160 regulation of anti-tumor signaling

Abstract: Somatic mutations can rewire tumor–immune interactions to favor cancer progression. Here, we define the functional impact of missense mutations in Herpesvirus entry…

Date: 2026-09-11

Metaplastic breast cancer: a clinicopathological analysis of nine cases highlighting diagnostic challenges and aggressive behavior

Abstract: Metaplastic breast cancer (MBC) is a rare and highly heterogeneous subtype of breast cancer associated with limited treatment options and a poor prognosis. We aimed to…

Date: 2026-09-11

Anlotinib plus PD-1 inhibitor in advanced soft tissue sarcoma: a real-world study on treatment patterns and treatment-emergent hypothyroidism

Abstract: Anlotinib was approved for advanced soft tissue sarcoma (STS) but validated biomarkers and optimal treatment patterns remain unclear. This study evaluated the efficacy,…

Date: 2026-09-11

Development of the perceived AI–physician consistency and trust scale for cardiology: a Delphi-based study

Abstract: Large language models (LLMs) have demonstrated considerable potential in cardiovascular diagnostic assistance and clinical decision support. A critical safety-related…

Date: 2026-09-11

Intracardiac echocardiography guided zero-fluoroscopy workflow versus conventional fluoroscopy-guided workflow in atrial fibrillation ablation: efficiency, safety, and operator experience

Abstract: Intracardiac echocardiography (ICE)-guided Zero-Fluoroscopy Workflow Group has been described in the literature. However, robust evidence simultaneously addressing…

Date: 2026-09-11

TCR ? CDR3 repertoire signatures in paired PBMC and BALF from children with mycoplasma pneumoniae pneumonia

Abstract: Mycoplasma pneumoniae (MP) is a leading cause of community-acquired pneumonia in children, yet the characteristics of the T cell receptor (TCR) repertoire in the local…

Date: 2026-09-11

Impact of anatomic complexity of congenital heart disease on growth retardation: a large retrospective cohort study

Abstract: Growth retardation (GR) is a significant comorbidity in children with congenital heart disease (CHD), particularly those with complex CHD. This study aimed to…

Date: 2026-09-10

Association of iron deficiency and iron-deficiency anemia with behavioral problems in children with autism: a cross-sectional study

Abstract: Iron deficiency (ID) and iron deficiency anemia (IDA) are common in children with autism spectrum disorder (ASD) and may contribute to behavioral problems. We examined…

Date: 2026-09-10

Hematopoietic stem cell transplantation for DOCK8 deficiency: durable immune reconstitution and long-term survival in 47 patients

Abstract: DOCK8 deficiency is a severe autosomal recessive combined immunodeficiency characterized by recurrent infections, severe atopy, immune dysregulation, and an increased…

Date: 2026-09-10

Comparable disease course in pediatric celiac disease with or without endoscopic confirmation at high anti-TG2-IgA-antibody titers

Abstract: The guidelines from the European Society for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) enable the diagnosis of celiac disease (CD) omitting…

Date: 2026-09-10